bachelor's at Bacharelado em Química from Universidade de São Paulo (2005) and doctorate at Biochemistry from Universidade de São Paulo (2010). , acting on the following subjects: bacterial motility, pilz, xanthomonas, c-digmp and eal domain. (Source: Lattes Curriculum)
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In this work, we will be working with two bacteria: the plant pathogen Xanthomonas citri (X. citri) and the human pathogen Leptospira interrogans (Lic). X. citri causes citrus canker in citrus crops, causing significant damage to Brazilian agriculture. It is a bacterium that uses an extracellular appendage, the type IV pilus (T4P), to move around (twitching). This filament is assembled th…
The CEPID B3 is a network with research hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) that will collaborate to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interaction…
Bacterial macromolecular protein secretion systems are large (multi-mega Dalton) multiprotein complexes that transport effector proteins through bacterial membranes to the extracellular milieu or directly into the cytoplasm of other cells. These systems also mediate the horizontal transfer of genetic material (conjugation) between bacterial cells and specialized homologous forms of these …
Our research group, in collaboration with researcher Dr. Edison Durigon of ICB USP, is developing a fast diagnostic tests to detect COVID-19. For this, we have already clone and express 4 fragments of the SARS-CoV-2 surface protein spike and have shown to be immonogenic against the serum of a human patient. For the production of the fast diagnostic test, proteins were produced on a large …
The goals of the project are the study of proteins of the human pathogen Leptospira interrogans. This bacterium is the causative agent of leptospirosis, a re-emerging infectious disease considered a zoonosis worldwide that affects several animals including humans. More than 500,000 cases of severe leptospirosis are reported per year, and in severe cases the patient ends up dying. Due to t…
Leptospira interrogans serovar Copenhageni is a human pathogen that causes leptospirosis, a worldwide zoonosis. About 10% of leptospiral infections may progress to multiple organ failure and pulmonary haemorrhages leading to death. As with many other bacterial pathogens, environmental changes are sensed by L. interrogans during the course of infection and may trigger transitions between d…
Type IV Pili (T4P) are retractable extracellular filaments of bacteria that allow twitching motility over surfaces. In the phytopathogen Xanthomonas citri pv. citri, T4P were also associated with biofilm formation and adhesion processes. In this organism, the secretin complex that forms the outer membrane channel for the passage of these filaments is being studied by electron cryomicrosco…
Xanthomonas citri pv. citri is the causative agent of citrus canker disease around the world, with important economic impacts in agriculture. This phytopathogen employs diverse mechanisms to colonize its host, survive in hostile environments, and acquire nutrients, including secretion systems, outer membrane vesicles, and extracellular appendages such as type IV pili (T4P). T4P are associ…
Bacteria from the Leptospira genus are responsible for leptospirosis, a zoonotic disease of public health importance. Due to challenges in its laboratory manipulation, many aspects of these bacteria remain underexplored. This includes intracellular signaling pathways, which will be studied in this project via heterologous expression of proteins of interest. The protein LIC_11920 from Lept…
(Only some records are available in English at this moment)
Leptospirosis is a zoonosis caused by bacteria of the genus Leptospira, a gram-negative spirochaete of translational motility. L. interrogans is the main cause of leptospirosis in humans, being characterized by varied virulence mechanisms such as tissue invasion, biofilm formation, adhesion to several types of cell lines, and secretion of enzymatic effectors which establish pathogenesis. …
Xanthomonas citri (XAC) is a phytopathogen that infects citrus trees, causing citrus canker. This bacterium possesses a secretion system that takes part in the competition for the environment, the Type IV Secretion System (T4SS), which is transmembrane machinery that contains an injection pilus responsible for the delivery of the secreted proteins into other microorganisms. One of these p…
(Only some records are available in English at this moment)
Bacteria and some eukaryotic organelles have nanomachines formed by large protein complexes that act in the process of secretion, in most of the cases, of macromolecules to the extracellular medium or directly into the host cell. These systems are called secretion systems and until now, were identified seven general classes of secretion systems and the chaperona/Usher system. There is a g…
| 3 / 3 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 14 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 26 / 23 | All research grants and scholarships |
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CV Lattes
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