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Lucas Tabajara Parreiras e Silva

CV Lattes

Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP)  (Institutional affiliation from the last research proposal)
Birthplace: Brazil

He is currently Professor at Department of Biomolecular Sciences of the Faculty of Pharmaceutical Sciences of Ribeirão Preto (DCBm/FCFRP-USP). He holds a bachelor's degree in Biological Sciences from the Federal University of São Carlos - UFSCar (2003), a Master's degree in Biochemistry from the Medical School of Ribeirão Preto - USP (2006) and a PhD in Biochemistry from the same institution (2009). He is currently a postdoctoral fellow at the Medical School of Ribeirão Preto at the University of São Paulo, maintaining active collaboration with groups from Brazil (UNIFESP, UFRGS) and also from Canada (University of Montreal) and Switzerland (Paul Scherrer Institut). His main aim is to study Intracellular Signaling, non-canonical functions of G Proteins and "biased agonism" in GPCRs, with potential for pharmaceutical and clinical application. He uses different modern approaches, based on the BRET technique, to evaluate the activation, translocation and regulation of G proteins and their effectors, but also for the analysis of the trafficking and mechanisms of GPCRs activation. He uses such techniques for pharmacological characterization of new drugs targeting GPCRs, and some clinically relevant drugs in the market, with the objective of elucidating the effects of the downstream events of the signaling cascades on cellular physiology, a poorly understood subject. In addition, understanding more deeply how the fine-tuned modulation of more upstream steps in signaling cascades may differentially interfere in downstream events, and lead to less deleterious effects on cellular metabolism, may potentially lead to the development of new drugs with greater clinical efficacy and fewer side effects. (Source: Lattes Curriculum)

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