CV Lattes
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
He is currently Professor at Department of Biomolecular Sciences of the Faculty of Pharmaceutical Sciences of Ribeirão Preto (DCBm/FCFRP-USP). He holds a bachelor's degree in Biological Sciences from the Federal University of São Carlos - UFSCar (2003), a Master's degree in Biochemistry from the Medical School of Ribeirão Preto - USP (2006) and a PhD in Biochemistry from the same institution (2009). He is currently a postdoctoral fellow at the Medical School of Ribeirão Preto at the University of São Paulo, maintaining active collaboration with groups from Brazil (UNIFESP, UFRGS) and also from Canada (University of Montreal) and Switzerland (Paul Scherrer Institut). His main aim is to study Intracellular Signaling, non-canonical functions of G Proteins and "biased agonism" in GPCRs, with potential for pharmaceutical and clinical application. He uses different modern approaches, based on the BRET technique, to evaluate the activation, translocation and regulation of G proteins and their effectors, but also for the analysis of the trafficking and mechanisms of GPCRs activation. He uses such techniques for pharmacological characterization of new drugs targeting GPCRs, and some clinically relevant drugs in the market, with the objective of elucidating the effects of the downstream events of the signaling cascades on cellular physiology, a poorly understood subject. In addition, understanding more deeply how the fine-tuned modulation of more upstream steps in signaling cascades may differentially interfere in downstream events, and lead to less deleterious effects on cellular metabolism, may potentially lead to the development of new drugs with greater clinical efficacy and fewer side effects. (Source: Lattes Curriculum)
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G-Protein Coupled Receptors (GPCRs) are the major membrane proteins involved in the signal transduction process. GPCRs have a typical structure of seven transmembrane alpha-helices and can be activated by a wide range of molecules of physiological relevance such as monoamines, peptides, neurotransmitters, hormones, among others, and regulate virtually all processes vital to the organism. …
After bibliographic research, we will identify resident proteins from different intracellular compartments, which could be used as markers for such compartments such as Golgi, endoplasmic reticulum, mitochondria and nucleus. After selecting the possible targets, we will construct markers for different intracellular compartments through Molecular Biology techniques, fusing such proteins, o…
G-protein coupled receptors (GPCRs) also known as seven transmembrane domains receptors (7TMRs) constitute the largest family of membrane receptors and are targets of about 50% of the drugs available on the market. It is now known that signaling of GPCRs is complex, since these receptors are able to activate various signaling pathways, in addition to different isoforms of protein G. It is…
G protein-coupled receptors (GPCRs) constitute the largest family of signal transducer proteins in mammals and are considered a major target for drug discovery. After stimulation, GPCRs activate G proteins and then recruit ²-arrestins, which lead to disruption of G protein signaling and initiation of the internalization process. Although b-arrestin was first discovered for its role in int…
| 1 / 1 | Completed research grants |
| 5 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 8 / 5 | All research grants and scholarships |
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