Professor at the Department of Biomolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto (DCBm/FCFRP-USP). Bachelor degree in Biological Sciences from the Federal University of São Carlos - UFSCar (2003), Master's degree in Biochemistry from the Faculty of Medicine of Ribeirão Preto - FMRP/USP (2006) and a PhD in Biochemistry from the same institution (2009). He was the researcher responsible for a Grant for Young Researchers from FAPESP, at the Faculty of Medicine of Ribeirão Preto, University of São Paulo (2017 - 2021), having supervised undergraduate and Doctorate students. He taught courses in the Postgraduate Program in Biochemistry - FMRP/USP from 2014 to 2021. He completed a Post-Doctorate and maintains active collaboration with excellence groups in Canada (University of Montreal) and Switzerland (Paul Scherrer Institut). He also maintains collaboration with groups in Brazil (UNIFESP, UFRJ, UFRGS). His research aims to study intracellular signaling, non-canonical actions of G Proteins and "biased agonism" in GPCRs, with potential for pharmaceutical and clinical application. He uses different modern approaches, based on BRET technique, to evaluate the activation, translocation and regulation of G proteins and their effectors, but also to analyze the trafficking and activation mechanisms of GPCRs. He uses such techniques for pharmacological characterization of molecules that target GPCRs, with the aim of elucidating the effects of non-canonical G protein signaling on cellular physiology. This process will lead to the identification of molecules with less harmful actions, potentially leading to the development of new drugs with greater clinical efficacy and fewer adverse effects. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
G-Protein Coupled Receptors (GPCRs) are the major membrane proteins involved in the signal transduction process. GPCRs have a typical structure of seven transmembrane alpha-helices and can be activated by a wide range of molecules of physiological relevance such as monoamines, peptides, neurotransmitters, hormones, among others, and regulate virtually all processes vital to the organism. …
After bibliographic research, we will identify resident proteins from different intracellular compartments, which could be used as markers for such compartments such as Golgi, endoplasmic reticulum, mitochondria and nucleus. After selecting the possible targets, we will construct markers for different intracellular compartments through Molecular Biology techniques, fusing such proteins, o…
G-protein coupled receptors (GPCRs) also known as seven transmembrane domains receptors (7TMRs) constitute the largest family of membrane receptors and are targets of about 50% of the drugs available on the market. It is now known that signaling of GPCRs is complex, since these receptors are able to activate various signaling pathways, in addition to different isoforms of protein G. It is…
G protein-coupled receptors (GPCRs) constitute the largest family of signal transducer proteins in mammals and are considered a major target for drug discovery. After stimulation, GPCRs activate G proteins and then recruit ²-arrestins, which lead to disruption of G protein signaling and initiation of the internalization process. Although b-arrestin was first discovered for its role in int…
| 1 / 1 | Completed research grants |
| 5 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 8 / 5 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID