Cristina de Oliveira Massoco Salles Gomes

• Abstract

  This project aims to verify the clinical outcome of an experimental immunotherapy associated with conventional treatments used in veterinary oncology and to evaluate the influence of the immunological context represented by an "immunogram" as a predictive factor in the clinical response of dogs with solid neoplasia. It will be based on a prospective clinical safety study comparing surviva…

  Hybrid dendritic-tumor cell immunotherapy in dogs with solid neoplasia: emphasis on immunogram and liquid biopsy evaluation, AP.R

• Abstract

  The tumor microenvironment consists of various cell types, including cells of the immune system. In particular, dendritic cells (DCs) have been widely studied in the tumor microenvironment, since these cells are considered the most potent antigen presenting cells (APCs) and are responsible for coordinating the adaptive immune response and play a key role in inducing and maintaining the an…

  Determination of dendritic cells of regulatory profile in the tumor microenvironment and its reprogramming with immunomodulators: study in canine melanoma, AP.R

• Abstract

  According to the Brazilian Institute of Geography and Statistics (IBGE), the equine population in Brazil is around 6 million, of which it is estimated that between 180 and 480 thousand suffer from melanoma, which leads to a considerable economic and genetic loss in the farming market.Melanoma is particularly common in horses with dapple-gray pelage, after the age of five. Current treatmen…

  Therapeutic vaccine for equine melanoma, AP.PIPE

• Abstract

  Neutrophils are a cell population known mainly for their important participation as phagocytes in infectious, inflammatory, and healing processes. In the cancer scenario, a new perspective about the action of this cell type has emerged, since the traditional idea that neutrophils are inert agents is being revisited. Evidence indicates that tumors can recruit neutrophils through the secret…

  Evaluation of tumor-associated neutrophils (TAN) and their relationship in the tumor microenvironment: study in canine oral melanoma, BP.IC

• Abstract

  In the treatment of chronic pain in domestic animals, such as osteoarthrosis, nonsteroidal anti-inflammatory drugs (NSAIDs) are the first line of pharmacological treatment usually associated with analgesics. The mechanism of action of these drugs is still being explored, while the best known is through the inhibition of cyclooxygenase(COX), an essential enzyme for the production of eicosa…

  Comparison of the effect of dipyrone and carprophen on inflammatory infiltrate through immunophenotyping synovial cells in an Arthritis model in rats, BP.IC

• Abstract

  Canine mastocytoma is a neoplasm of high incidence and high malignancy. Currently, the search for new prognostic factors and treatment modalities for this neoplasm is increasing. A possible prognostic and predictive tool would be the use of hematological indices (NRL, PLR, MLR and SII) - obtained through blood markers present in hemograms - to compose the immune profile of patients with m…

  Analysis of complementary parameters based on the immune profile for prognosis of dogs with cutaneous mastocytoma, BP.IC

(Only some records are available in English at this moment)