graduate at Licenciatura/Bacharelado em Química from Universidade Federal de São Carlos (1979), master's at Biochemistry from Universidade de São Paulo (1982) and ph.d. at Biochemistry from Universidade de São Paulo (1987). Has experience in Biochemistry, acting on the following subjects: redox signaling, nitric oxide, free radicals, and reactive oxygen species. (Source: Lattes Curriculum)
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Cancer development is closely related to a condition of chronic inflammation. To this condition, markers of tumor progression such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemoresistance, and metastasis are frequently associated. Within the inflammatory tumor microenvironment, redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) pl…
Cancer development is closely related to a condition of chronic inflammation. To this condition, markers of tumor progression such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemoresistance, and metastasis are frequently associated. Within the inflammatory tumor microenvironment, redox processes mediated by Reactive Oxygen Species (ROS) and Nitric Oxide (NO) pl…
Nitric oxide (NO) is a free radical generated from the oxidation of L-arginine in a process catalyzed by the enzymes nitric oxide synthases (NOS). Three NOS isoforms are known: nNOS (neuronal), eNOS (endothelial) and iNOS (inducible). NO* can stimulate cell proliferation or cell death according to cell type and local free radical concentration. NOS isoforms are found in different tumor ce…
(Only some records are available in English at this moment)
The World Health Organization (WHO) points to cancer as one of the leading causes of death in the world. The microenvironment of the tumor can be described as chronic inflammation, as a "wound" that does not heal. In this chronic inflammatory environment, inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO) are produced, which influence the processes of cell signal…
The greater or lesser prevalence of Nitric Oxide (NO) or Reactive Oxygen Species (ROSs) associated with different stages of tumor development should guarantee the survival of tumor cells in each stage of development. This balance could potentially modulate the oncogenic signaling pathways responsible for the different stages of tumor development. In this project we will carry out in vivo …
According to the World Health Organization (WHO), Cancer is the second leading cause of death in the world and in 2018 has caused more than nine million deaths. Among the various types of Cancer, Colorectal Cancer, which includes solid tumors in one segment of the large intestine (the colon) and the rectum, is the third most frequent type of Cancer in men and the second in women in Brazil…
Cancer is one of the major global public health problems, being the second leading cause of death worldwide. It is defined as a set of diseases that in general are characterized by mutations in genes that have the function of regulating cell proliferation, differentiation and death. In Brazil, more than 625 thousand new cases are estimated for each year of the 2020-2022 period, which are …
Colorectal cancer (CRC) and human melanoma are characterized by their aggressiveness and metastatic power, associated with a poor prognosis for patients. These properties are related to changes in cell homeostasis, characterized by genetic mutations, excessive production of reactive species, hypoxia, shortage of nutrients, among other factors. These changes enable metabolic reprogramming …
The greater or lesser prevalence of Nitric Oxide (NO) or Reactive Oxygen Species (ROSs) associated with different stages of tumor development should guarantee the survival of tumor cells in each stage of development. This balance could potentially modulate the oncogenic signaling pathways responsible for the different stages of tumor development.In this project we will carry out in vivo t…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 15 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 25 / 12 | Completed scholarships in Brazil |
| 45 / 24 | All research grants and scholarships |
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CV Lattes
ORCID