Graduate at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1993), master's at General Biology from Universidade Estadual de Campinas (1996) and ph.d. at General Biology from Universidade Estadual de Campinas (1999). Has experience in Morphology, focusing on Anatomy, acting on the following subjects: c57bl6j, nervo ciático, tubulização, regeneração nervosa and pedegeneração. (Source: Lattes Curriculum)
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Duchenne Muscular Dystrophy (DMD) is a severe genetic muscle disease characterized by failures in the synthesis of the protein dystrophin, inducing progressive muscle degeneration and weakness, leading the patient to death. The progression of the disease results in synaptic changes in the CNS as well as in the neuromuscular junctions. In addition, the axons of the neurons enter into a cyc…
Functional recovery of the peripheral nervous system (PNS) injured is frequently and highly variable, leading to persistent sensory/motor deficits with poor quality of life and productivity. Biomimetic biomaterials that release continuously bioactive molecules offer a promising approach to optimizing the microenvironment during nerve regeneration. New technologies such as three-dimensiona…
Functional recovery of the peripheral nervous system (PNS) injured is frequently and highly variable, leading to persistent sensory/motor deficits with poor quality of life and productivity. Biomimetic biomaterials that release continuously bioactive molecules offer a promising approach to optimizing the microenvironment during nerve regeneration. New technologies such as three-dimensiona…
(Only some records are available in English at this moment)
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the upgrade of the Institute network hardware, animal facilities improvements, electric instalation renewal and establishement of a NB3 lab are proposed. (AU)
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the instalation of different gases stations, upgrading datacenter infrastructure and renovation of laboratories are proposed. (AU)
The present application aims at upgrading the infrastructure of the Institute of Biology / Unicamp. In this way, the instalation of different gases stations, upgrading datacenter infrastructure and renovation of laboratories are proposed. (AU)
(Only some records are available in English at this moment)
Amyotrophic Lateral Sclerosis (ALS) is a disease characterized by the degeneration of motor neurons, resulting in muscle weakness and atrophy, fasciculations, progressive paralysis, and speech and swallowing impairments. Death occurs two to five years after the onset of symptoms, usually due to respiratory failure. ALS is classified into two main types: familial, of hereditary origin, and…
Spinal nerve root lesions can occur after trauma and pathological processes, leading to dysfunction of brachial and lumbosacral plexuses. These lesions can be avulsion or crush, generating neuronal death and synaptic loss, consequently, causing motor and sensory dysfunctions. Local inflammation is mediated by astroglial and microglial cells, giving rise to a pro-inflammatory profile. Drug…
Accidents that reach peripheral nerves may cause, in more severe cases, definitive muscle atrophy, loss of sensibility and movement on the affected limb. The nervous system regenerative mechanism is still little known, being relevant to the metabolic components of the repair process. This research aims to investigate how Nicotinamide Nucleotide Transhydrogenase acts - which in recent stud…
(Only some records are available in English at this moment)
Compressive root lesions are characterized by changes in the spinal cord's nervous microenvironment. Among these changes, the excitotoxic effect caused by glutamate, gliosis, and the subsequent maladaptive plasticity events stand out. Glutamate is an excitatory neurotransmitter that activates, among others receptors, the NMDAr ionotropic receptor. In light of the findings of how excessive…
Spinal cord injuries generate significant degeneration of motoneurons, loss of synapses, formation of glial scar and chronic inflammation, hampering functional recovery. In order to provide neuroprotection and regeneration, early surgical interventions and treatments that positively modify the neuronal microenvironment are necessary. In this sense, the use of neuroprotective and chemotact…
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects motor neurons progressively, causing progressive weakness and muscle atrophy, leading to death frequently due to respiratory arrest. ALS can be classified into two main types, which differ in etiology. The familial type has a hereditary origin, while sporadic type represents the vast majority of cases (90%), a…
(Only some records are available in English at this moment)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the motor system. The cause of the disease is still unknown, but some protein mutations have been linked to the pathological process. Previously, it has been considered that immune abnormalities might contribute to the pathogenesis of disease. However, more recently it has become apparent that the immune re…
Dorsal root injury leads either to chronic pain or paresthesia, resulting in loss of function of the affected arm, even when motor roots remain intact, due to damage to proprioceptive fibers which lose contact with motoneurons. Regeneration through the dorsal root entry zone is difficult due to inhibitory molecules within the Central Nervous System, but possible in crushing injuries. In t…
The interaction between motoneurons and glial cells has a crucial role for survival, regulation of functional state and synaptic connectivity in the spinal cord. Understanding the basic functions of glial cells and motoneuron interaction will contribute to the development of new strategies in order to promote regeneration after injury. After lesion, glial cells also undergo a series of mo…
(Only some records are available in English at this moment)
| 6 / 6 | Ongoing research grants |
| 32 / 29 | Completed research grants |
| 10 / 10 | Ongoing scholarships in Brazil |
| 42 / 36 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 96 / 86 | All research grants and scholarships |
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CV Lattes
ORCID