graduate at Odontologia from Universidade de São Paulo (1994), graduate at Letras from Universidade de São Paulo (2002), master's at Odontology from Universidade de São Paulo (1998) and ph.d. at Odontology from Universidade de São Paulo (2001). Has experience in Odontology, acting on the following subjects: dentistry, undernutrition and tissue repair, inflammation and alternative drugs, laser therapy and photodynamic therapy. (Source: Lattes Curriculum)
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Low level laser therapy has been adopted for the prevention and treatment of oral mucositis. This lesion is derived from an intense oxidative stress caused by radiotherapy and chemotherapy. The oxidative stress induces the formation of oxidized bases and activates a DNA-damage response (DDR) in neoplastic and normal cells. The DDR is composed mainly by mechanisms of non-homologous end-joi…
Oral squamous cell carcinoma (OSCC) is a high morbidity cancer, which leads high frequency of recurrence and resistance to conventional treatments. Photodynamic therapy (PDT) has been applied in early phases of OSCC, with a number of cases showing promising indexes of complete remission of the tumor. It is unknown, however, if OSCC cells can be resistant to the PDT, mainly in situations o…
The use of photodynamic therapy (PDT) in treatment of oral premalignant lesions (OPM) has been focused on recent researches. PDT is based on an electromagnetic interaction with a photo sensitizer and tissue oxygen, forming reactive oxygen species (ROS) that cause death in metabolically active cells. The aim of this study is to establish the anatomic and chronologic relationship of cellula…
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Oral mucositis (OM) is an inflammatory condition derived from the cytotoxic effect of chemotherapy, mainly from 5-FU, melphalan, and methotrexate. After chemotherapy exposure, intense oxidative stress and DNA damage can occur. Photobiomodulation (PBM) is indicated for the prevention and treatment of OM, due to its properties of inflammatory modulation and repair improvement; however, the …
Chemotherapy agents 5- fluorouracil (5-FU), methotrexate (MTX) and melphalan are widely used in the treatment of malignant neoplasms and hematopoietic stem cell transplantation conditioning. These agents, however, induce intense production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), which in the oral mucosa, can lead to the development of oral mucositis. Oxidativ…
Chronic alcoholism impairs the tissue repair, altering the inflammatory response and the cell proliferation and differentiation. During the wound reepithelization, the epithelial cells exhibit different expression of adhesion molecules, such as E-cadherin and Beta-catenin, acquiring a mesenchymal phenotype and high capacity of migration. The effect of ethanol on this process is unknown in…
The aim of this study is to analyze the dendritic cell (DC) repopulation during wound healing on oral mucosa in individuals under chronic ingestion of ethanol. Some studies have demonstrated that acute ingestion of ethanol leads to inhibition of differentiation and migration of DC on skin, but in oral mucosa this effect was not described. In the present study we will verify if the chronic…
| 4 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 4 / 3 | Completed scholarships in Brazil |
| 9 / 8 | All research grants and scholarships |
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CV Lattes
ORCID