GLAUCIUS OLIVA is Full Professor of the University of São Paulo. He studied Physics and Electronics Engineering as an undergraduate of the University of São Paulo and subsequently obtained his PhD in Protein Crystallography and Structural Biology at the University of London in 1988l. His main research interests are structural biology and medicinal chemistry and its application in drug design and discovery, with a particular focus on parasitic infectious tropical diseases that affect the population of Brazil and other developing countries. His work on Chagas disease has led to the discovery of several new inhibitors of parasitic enzymes, promising new drugs for the treatment of this endemic illness. He was the key leader in the establishment of Protein Crystallography research in Brazil, including the development of the first protein crystallography beamline at the Brazilian National Synchrotron Laboratory. He has lead the first graduate program on Biomolecular Physics in the country and more recently created the first undergraduate course on Biomolecular Physical Sciences in Brazil. He was Vice-president of the Brazilian Society of Biochemistry and Molecular Biology-SBBq (2005-2007). Prof. Oliva has lead several projects in collaboration with Brazilian pharmaceutical industries, including programs of biodiversity screening for new natural products drug candidates. Amongst other prizes, he is Member of the Brazilian Academy of Sciences, Member of the National Order of Scientific Merit of Brazil, International Scholar of the Howard Hughes Medical Institute (1997-2001), Member of TWAS (The World Academy of Sciences for the advancement of science in developing countries) and Fellow do Birkbeck College - University of London. He was Director (2010) and President (2011-2015) of the Brazilian National Council for Scientific and Technological Development (CNPq); founder and member of the Governing Board of the Global Research Council (GRC). (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| An agenda for forgotten diseases |
| Promising structures |
| Estructuras prometedoras |
| The essence of molecules |
| The essence of molecules |
| La esencia de las moléculas |
| A promising forecast |
| Pronósticos optimistas |
| News published in Agência FAPESP Newsletter about the researcher |
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The Center for Research and Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborativeresearch projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of RibeiraoPreto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), theInst…
The Center for Research and Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborativeresearch projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of RibeiraoPreto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), theInst…
The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborative research projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of Ribeirao Preto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), the Institute of C…
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The rapid spread of the COVID-19 global pandemic with exponential growth in cases in Brazil and worldwide, there is great concern about the lethality of the disease and the saturation of hospital beds to treat severe cases. Although the search for an effective vaccine is urgent, any development should require one to two years before it is approved, so there is no expectation that they can…
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In the last two decades, coronaviruses (CoVs) were responsible for three major epidemics: SARS, MERS, and currently COVID-19, caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2). The CoV genome consists of a positive-sense single-stranded RNA (~ 30 kb), which comprises the 5' and 3' UTRs (untranslated regions) and the ORFs (open reacting frames) 1a and 1b, which occupy …
The emergence of a new coronavirus in 2019 generated a pandemic that has lasted until now, so the search for candidates for new antiviral drugs against SARS-CoV-2 has become a priority. The nonstructural protein Nsp13, encoded in the viral genome, is an enzyme with helicase activity dependent on ATP hydrolysis, being essential for viral replication and, therefore, an attractive target wit…
Emerging and reemerging viruses will always constitute a threat and a challenge to global public health. Despite the recent COVID-19 pandemic highlight, the emergence of diseases caused by viral agents is not a new phenomenon. In Brazil, for at least 30 years, there has been the emergence and re-emergence of viral diseases, caused mainly by arboviruses, such as the Chikungunya epidemic th…
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Emerging and reemerging viruses will always constitute a threat and a challenge to global public health. The emergence of a new type of coronavirus (SARS-CoV-2), in December 2019, generated an epidemic that has lasted until now and has already resulted in more than 174,418,411 cases worldwide, with 17,130,234 of them in the Brazilian territory. Statistics still show about 3,757,791 deaths…
The Chikungunya virus (CHIKV), which causes Chikungunya fever, is an arbovirus transmitted by the Aedes aegypti mosquito, which periodically causes epidemics around the world. Since the 2014 outbreak in Brazil, the number of cases of CHIKV infection has increased and could become a serious public health problem. A viral infection causes several symptoms, which can result in arthritis and …
The Zika virus is an arbovirus transmitted by the bite of the Aedes aegypti mosquito, which became a public health problem during the 2015/2016 outbreak in the Americas and mainly in Brazil, where it was related to cases of microcephaly and Guillan-Barré syndrome. The identification of autochthonous cases in 87 countries in 2019, shows ZIKV's enormous potential to emerge in the future as …
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Human cytomegalovirus (HCMV) is a beta-herpesvirus belonging to the Herpesviridae family and Cytomegalovirus genus. The virus is widely spread among the world population establishing a latent infection, and it represents one of the most frequent causes of death among immunocompromised patients and one of the main causes of congenital birth problems. The viral genome is composed by a linea…
Yellow fever virus (YFV) is an acute viral hemorrhagic disease transmitted by infected mosquitoes. The YFV is endemic in tropical areas of Africa and Central and South America. Large epidemics of yellow fever occur when infected people introduce the virus into heavily populated areas with high mosquito density and where most people have little or no immunity, due to lack of vaccination. …
Chagas disease and leishmaniasis are infectious diseases caused by protozoan parasites of the genus Trypanosoma and Leishmania, respectively. Chagas disease is endemic in Latin America, affecting approximately 8 million people. Nearly 10,000 deaths occur each year as result of the clinical consequences of the disease. Leishmaniasis occurs in 98 countries and approximately 1.3 million new …
The understanding and prediction of protein-protein molecular complex formation are fundamental for modern biomedicine and biotechnology efforts with protein plasticity being one of the main challenges for such predictions. Recent advanceson the use of Nuclear Magnetic Resonance data as restrains in molecular dynamics simulations (NMR-MD) allow us to obtain protein conformational ensemble…
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