graduate at Farmacia e Bioquímica Ribeirão Preto from Universidade de São Paulo (1978), master's at Pharmacy from Universidade de São Paulo (1995) and ph.d. at Chemistry from Universidade de São Paulo (1998). Has experience in Protein Chemistry, acting on the following subjects: Proteomics and Glycomics of cancer and stem cell. (Source: Lattes Curriculum)
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Glial cells (astrocytes, oligodendrocytes, microglia and ependymocytes), the most numerous in the human brain, provide nutritional support, blood, structural and defense to neurons. They can mutate giving rise to glial tumor cells or glioma, of which 70% are derived from astrocyte cells. The development of tumors is often attributed to an accumulation of genetic changes that allow cells t…
Gliomas are the most malignant of brain tumors, they are very heterogeneous, and have features like high cell proliferation, hyperplasia, necrotic areas and extensive formation of new blood vessels. Among them, astrocytomas correspond to 60% of brain tumors and usually affect the adult population, the survival prognosis is poor, or up to 12-14 months of life, since they have a tendency to…
This proposal will investigate the profiling of N-glycans and O-GlcNAc modified proteins in melan-a, TM1 and TM5 cell lineages using a glycoproteomic approach. The cell lineages represent a murine model of melanoma progression: Melan-a, non tumorigenic lineage was obtained from normal melanocytes, while TM1 and TM5 are tumorigenic cells derived from melan-a that present phenotype of verti…
(Only some records are available in English at this moment)
The alternative splicing, in the context of the diversity of protein products from a restricted number of genes, carries great importance for an understanding of the mechanisms that govern the cellular physiology of different tissues. In this sense an understanding of how mechanism is regulated, especially by the sayings of splicing, becomes important. Among them, as proteins of the NOVA …
Stressful stimuli trigger in most cell lines stress-reducing and cell-survival mechanisms such as Unfolded Protein Response (UPR). This type of cellular stress response causes an increase in vesicle secretion by RE and Golgi apparatus, which when are secreted by these cells are named exosomes. In the body fluids, such as blood, urine, saliva and liquor, these microvesicles contain mRNAs, …
Medulloblastoma, the most common tumor of the central nervous system (CNS) in childhood, represents approximately 20% of all pediatric intracranial neoplasms. It is classified as grade IV tumor by the World Health Organization (WHO) and divided into five subtypes: classic, desmoplastic/nodular, with extensive nodularity, anaplastic and large cell. The current challenge in medulloblastoma …
(Only some records are available in English at this moment)
| 8 / 7 | Completed research grants |
| 8 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 17 / 12 | All research grants and scholarships |
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CV Lattes
ORCID