Christie Ramos Andrade Leite Panissi in research grants and scholarships supported by FAPESP.
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Chronic pain has a high worldwide prevalence, being considered a public health problem with a high financial and social cost. The treatment of patients with chronic pain is challenging because, in some cases, the therapeutic efficacy is not adequate. Additionally, chronic pain is associated with critical emotional disorders such as anxiety and depression, making its pharmacological approa…
The carbon monoxide (CO) is a neuromodulator gas which may be involved in apoptosis, cellular proliferation, inflammation and the emotional behavior, for instance, the anxiety modulation. The CO can act on the anxiety in a process dependent of kinase protein C which is activated by soluble guanylate cyclase and 3'-5'-guanosine monophosphate. This mechanism can modulate noradrenergic neuro…
(Only some records are available in English at this moment)
Pain sensitivity involves the detection of harmful stimuli and activation of central nervous system circuits, being modulated through descending pathways. Pain modulation would involve the integration of endogenous systems activity, such as opioids and cannabinoids. In addition, the carbon monoxide pathway (HO-1/CO) is also involved in pain modulation, and its induction is capable of prod…
The rat is a social animal and lives in well-defined colonies composed of males and females. Aiming to study social behavior, Bonuti and Morato (2018) proposed a sociability test by decreasing the interference that one animal has over the other during the experimental sessions, and Bonuti (2018) used it to selectively breed rats that showed greater (SOC +) and less (SOC-) tendency to soci…
Painful sensitivity is a somatovisceral perception that has, in addition to the sensory-discriminative component, common to other sensory modalities, an affective-motivational component, which makes this sensitivity unique to each individual. Among the pain modulation mechanisms, cognitive and emotional aspects are of paramount importance, especially in persistent and chronic pain cases. …
Epidemiological studies show that Generalized Anxiety Disorder (GAD) and chronic pain are highly prevalent and debilitating diseases in the world. GAD refers primarily to a persistent and excessive state of worry, while chronic pain is a pain that persists or repeats after recovery phase of an injury. Concomitant to these data, chronic or persistent pain is related to various psychiatric …
The conditions of persistent or chronic pain are often accompanied by disordersemotional and cognitive. These dysfunctional or maladaptive changes in aversive/motivational circuits probably contribute to the challenges of treating neuropathic pain. However, experimental and methods used to measure the affective dimension of pain are still scarce in the literature. Considering the neuroche…
(Only some records are available in English at this moment)
The neuropathic pain, it develops as a consequence of an injury or disease that affects somatosensory pathways in the peripheral or central nervous system and accompanies many systemic diseases. Among the neurochemical systems of pain modulation, the cannabinoid system is an important endogenous system that participates in the circuit of pain sensitivity, functioning parallel to the opio…
Orofacial pain has a high prevalence associated with debilitating disorders in modern society involving the neck, face, head and all intra-oral structures. In addition, temporomandibular joint (TMJ)-associated inflammation is considered to be one of the reasons for the pain reported by patients with temporomandibular disorders (TMD). To study orofacial pain mechanisms, although many anima…
| 1 / 1 | Ongoing research grants |
| 8 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 19 / 12 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 32 / 21 | All research grants and scholarships |
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