CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Breno Esposito has a BSc in Chemistry (1994) and a MSc (1997) and PhD (2000) in Inorganic Chemistry by the Universidade de São Paulo. He was a postdoctoral fellow at the Hebrew University of Jerusalem (2000-2002) working on iron metabolism and fluorescent probes for iron. He was a visiting faculty to the University of Queensland (Australia, 2014) and to the Albert Einstein College of Medicine (USA, 2019-2020). Currently, he is an Associate Professor at Universidade de São Paulo. He has experience in Inorganic Chemistry, Bioinorganic Chemistry, Chelation Therapy and the development of Metallodrugs. (Source: Lattes Curriculum)
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Coral reefs are fundamental structures for aquatic ecosystems and, therefore, for cultural and economic activities. Corals are invertebrates that live in symbiosis with microalgae known as zooxanthellae, and this relationship can be affected by environmental stressors (temperature and ocean acidification), leading to the bleaching process, debilitating and even preventing the animal's sur…
Iron overload is a debilitating condition for patients, leading to decreased quality of life. At the same time, iron is a crucial nutrient also for parasites and tumor cells. Iron chelators are high affinity molecules that display several possibilities of clinical use: (i) reducing metal overload; (ii) delivering toxic metals to selected targets; (iii) scavenging essential metals from sai…
Iron overload is harmful for patients who show a significant decrease in quality of life. Simultaneously, iron is also a crucial nutrient for parasites and tumor cells. Iron chelators are high affinity molecules which have different possibilities of clinical use: (i) attenuators of metal overload; (ii) deliverers of toxic metals to selected targets; (iii) sequestrants of essential metals …
Patients undergoing myeloablative conditioning for hematopoietic stem cell transplantation (HSCT) may present iron overload due to underutilization (suppression of erythropoiesis) and release from liver and bone marrow cells (toxicity). There is a concern that forms of free and reactive iron can be involved in the occurrence of toxicity and complications commonly observed in the early set…
(Only some records are available in English at this moment)
Candidiasis is an opportunistic mycosis that can affect several places in the body, is caused by Candida spp. Although this species lives in the microbiota of 80% of the healthy population in commensalism, when there is an imbalance in immunity, vaginal pH, or dysfunction of the intestinal microbiota, this yeast becomes pathogenic. With the increase in immunosuppressed patients, this dise…
Corals are invertebrates that live in symbiosis with microalgae of the Symbiodiniaceae family, called zooxanthellae, which provide the animals with photosynthetic products in exchange for protection and constant exposure to the sun. However, this symbiosis is sensitive to environmental impact, having recently resulted in blanching episodes (expulsion of microalgae by coral), with negative…
Iron overload is a harmful condition for patients, who have a significant decrease in quality of life. At the same time, iron is a crucial nutrient also for parasites and tumor cells. Iron chelators are high-affinity molecules that present several possibilities for clinical use: (i) metal overload attenuators; (ii) hijackers of essential metals of those same targets; (iii) metalloenzyme i…
Iron overload is a harmful condition for patients, who present a significant decrease in quality of life. Iron chelators are high affinity molecules that present several possibilities for clinical use: (i) metal overload attenuators; (ii) deliverers of toxic metals to selected targets; (iii) hijackers of essential metals of these same targets. Desferrioxamine (DFO), a bacterial siderophor…
Iron overload is a harmful condition for patients, who present a significant decrease in quality of life. Iron chelators are high affinity molecules that present several possibilities for clinical use: (I) metal overload attenuators; (II) deliverers of toxic metals to selected targets; (III) hijackers of essential metals of these same targets. Desferrioxamine (DFO), a bacterial siderophor…
Metal ions are highly versatile species in biochemistry, with a wide variety of metals crucial to biological processes. However, the overloading of the so-called essential metals can trigger damage, often due to the fact that there are no strategies dedicated to their natural elimination. This project aims at the prospection of extracts of Brazilian marine sponges in order to obtain chela…
(Only some records are available in English at this moment)
Iron overload is responsible for a plethora of tissue damages, all of them due to the onset of labile pools of iron that include redox-active forms of this metal in the organism. Ideal ligands for iron chelation therapy should be able to penetrate the overloaded tissue, bound the metal as a stable, non-redox-active form, ferry it out from cells and transfer it to circulatory chelators (ei…
| 1 / 1 | Ongoing research grants |
| 8 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 12 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 25 / 22 | All research grants and scholarships |
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