CV Lattes
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ORCID
Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Director of Brazilian National Laboratory for Biosciences (LNBio) from the Center for Research in Energy and Materials (CNPEM). Graduation in Medicine (1984), Fellowship in Cardiolgy (1985-1988), PhD - Human Physiology (1989-1991). Pos-doctoral Fellowship at the Medical College of Wisconsin (1993-1995). Research interests in signaling mechanisms in cardiomyocytes, pathogenesis and physiopathology of cardiac hypertrophy and failure and Drug Discovery and Development. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| A place in the sun |
| The heart's sensor |
| El sensor del corazón |
| Unrestricted flow |
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
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| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The study of protein interactions is an important field to understand protein functions. This is, however, one area of great experimental difficulties due to inherent complexity of proteins and peptides. High resolution structural tools (i.e. X-Ray diffraction and Nuclear Magnetic Ressonance are the de facto methods for these studies. However, most proteins and protein complexes are not a…
The objective of this proposal is to mount the infrastructure of the building that will house the electricity generating plant of the National Center for Research in Energy and Materials - CNPEM. This plant operates in emergency mode when there is an interruption in the power supply from the dealership (CPFL) during peak hours where the amount billed by kWh is six times greater than the v…
On this Project will be presented the necessity for intellectual property protection, operational and administrative information of CNPEM to ensure safety and functional contigency for the Site.Due to the rapidly and continuous growth of CNPEM in recent years, several expansions in IT infrastructure occurred at an accelerated rate. these expansions have increased the capabilities and tec…
(Only some records are available in English at this moment)
The research in pathogenesis of hypertrophy and heart failure has an important frontier in the study of cell signaling circuits involved in cardiomyocytes response to pathophysiological stimuli. The various circuits involved in this process have complex configurations, composed of proteins from distinct functional classes, including kinases, phosphatases, proteases, adapter proteins, chap…
Recently, were identified sarcomeric proteins interactions with signalling partners that are able to move among subcellular compartments of cardiomyocites. It was also observed that the cardiac fibers are sensitive to mechanical stress, which respond through activation of signaling pathways (a phenomenon called "mechano-signalling" or "signal mechanotransduction"). It is believed that thi…
Germline mutations in Shp2 gene cause Noonan Syndrome (NS) and LEOPARD syndrome (LS), genetic disorders that include heart defects and increased propensity to cancer,amoung its clinical manifestations. We showed earlier that Shp2 associates and negatively regulates FAK activity in cardiomyocytes, and directly interacts with FAK in vitro. We have seen that the modulation of FAK activity by…
(Only some records are available in English at this moment)
| 18 / 11 | Completed research grants |
| 38 / 8 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 57 / 19 | All research grants and scholarships |
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