CV Lattes
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Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Lead Researcher at LNBio - CNPEM. Holds a degree in Biological Sciences from UFSCar (2003) and a Ph.D. in Sciences from the Institute of Physics at USP São Carlos, in the area of Applied Molecular Physics (2008). Conducted part of her postdoctoral studies at the University of Houston and The Methodist Research Institute (2009), and another postdoctoral period at the University of São Paulo, in the Protein Crystallography group at IFSC (2008 and 2010). Has expertise in Biochemistry, Cellular and Molecular Biology, Structural Biology, Biophysical Techniques, and Tissue Engineering. Works on various topics, such as structural characterization of proteins, assembly and stabilization of protein-protein and protein-DNA complexes, spectroscopic studies, analysis of structural stability and biophysics of proteins, and characterization of biotherapeutics.Participated in projects focused on developing diagnostic tests and the COVID task force at CNPEM. Since 2018, started a research line in Tissue Engineering, conducting studies on the development and characterization of reconstructed skin and 3D cultures and organoids, seeking alternative methodologies to the use of animals and toxicological studies through the use of microfluidic systems. Her research is primarily focused on metabolic syndrome, obesity, diabetes, tissue bio-printing, and skin remodeling.Serves as the coordinator of the Spectroscopy and Calorimetry Laboratory and the 3D Cultures and Microfluidics Laboratory at LNBio - CNPEM and as the coordinator of the Tissue Engineering Platform at LNBio/CNPEM. Represents LNBio as a Central Laboratory associated with RENAMA and is affiliated with the International Society of Microfluidic Systems (iMPS). Has been a CNPq productivity fellow since 2019. (Source: Lattes Curriculum)
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Obesity, type 2 diabetes, and fatty liver disease are chronic diseases characterized by increased body fat, inflammation, and insulin resistance. Its increasing numbers of new cases are considered alarming and therefore the development of new therapies is of great importance. In this context, PPAR³ is a modulation target, acting effectively in adipogenesis and insulin sensitization. Sever…
Obesity and type 2 diabetes are chronic diseases characterized by increased body fat and insulin resistance. The growing number of new cases per year have been considered alarming and, for this reason, the development of new therapies has considerable importance. In this scenario, nuclear receptors play fundamental roles, being important modulation targets. The PPAR³ is one of these targe…
Obesity and type 2 diabetes are chronic diseases characterized by increased body fat and insulin resistance. The growing number of new cases per year have been considered alarming and, for this reason, the development of new therapies has considerable importance. In this scenario, nuclear receptors play fundamental roles, being important modulation targets. The PPAR³ is one of these targe…
Nuclear Receptors (RNs) are proteins that compose a superfamily of transcription factors generally modulated by ligands. The RNs are involved in several functions of the life organisms, regulating gene transcription related to many processes as differentiation, development, metabolism, and reproduction, among others. Additionally, the RNs are directly related to pathologies, being targets…
(Only some records are available in English at this moment)
The Metabolic Syndrome is a cluster of conditions that happens together. These conditions disrupt the body glycose levels homeostasis, which leads to a resistance to respond to insulin. The thiazolidinediones (TZDs) are the main drug for the treatment of Metabolic Syndrome. It targets the ligate-dependent nuclear receptor (RN) PPAR³ where it acts as a strong agonist. The PPAR³ is a key pl…
Nuclear receptors are regulators of various processes of animal metabolism and therefore play an important role in acting as drugs for various metabolic diseases. The peroxisome proliferator-activated receptor gamma (PPAR³) is the master regulator of general lipid metabolism and insulin sensitivity, being the main responsible for the process of adipogenesis. Its activation occurs through …
Obesity and metabolic syndrome are global epidemics that tend to grow. In these conditions the transcription of several genes is altered, including that of adiponectin, a protein responsible for a set of metabolic regulations that result in the sensitization of the organism to insulin, whose expression is decreased in obese individuals, being that the main factor for the development of di…
(Only some records are available in English at this moment)
Metabolic syndrome is a cluster of conditions that happens simultaneously within the body and may lead to clinical conditions such as obesity and type II diabetes. This work focus on the structural investigation of the deacetylase SIRT1 and the nuclear receptor PPAR³, a master regulator of adipogenesis and glucose homeostasis. Recently studies demonstrate that PPAR³ controls adipogenesis …
PPAR gamma is the main regulator of adipogenesis and insulin sensitization, and therefore it is widely studied as a therapeutic target for modulating the metabolic processes that involve obesity. PGC-1 alpha is a coregulator partner of PPARgamma, it acts together to regulate genes involved mainly in beta-oxidation and browning processes. Previous results from our group have shown that the…
Nuclear Receptors (NRs) belong to a superfamily of transcription factors regulated by ligands. They act on the transcription of specific genes and they are involved in several processes such as cell proliferation, homeostasis, metabolism and others. The receptors COUP-TFII (Chicken ovalbumin upstream promoter-transcription factor) and GR (glucocorticoid receptor) have been associated to d…
PPARs and LXRs are lipid-activated transcription factors that belong to the nuclear receptor superfamily. Both types of receptors are activated by ligands from dietary lipids, such as fatty acids and cholesterol metabolites (oxysterols), respectively. They are intrinsically involved in metabolic pathways related to inflammation, diabetes, obesity and cardiovascular diseases, which make th…
The Peroxisome Proliferator-activated Receptor beta/delta (PPAR²) is a transcription factor, member of the nuclear receptor's superfamily. This protein can be found in several human tissues, mainly in those involved in high lipid metabolism and dependent on cell proliferation and differentiation, such as skin, intestine, placenta, adipose tissue, brain and skeletal muscle. PPAR² heterodim…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 19 / 14 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 31 / 25 | All research grants and scholarships |
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