CV Lattes
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Inglaterra
Graduated in Physiological Sciences and History from the University of California, Los Angeles (UCLA) (1999); master's degree in Biology from California State University (CSULA), Los Angeles (2003), Masters in Bioinformatics Johns Hopkins University (JHU) (2006) and Ph.D. in Genetics from the University of Southern California (USC) (2011). He did post-doctoral fellow in genetics at the University of Southern California. Has experience in the areas of General Biology, with emphasis on molecular biology, epigenetics, DNA methylation, Cancer, study of the genome. He participated in the analysis of data from the consortium "Human Genomics Cancer Research." And experienced in designing and / or development of algorithms in Bioinformatics / Molecular Biology for analyzing massive amounts of data (high data throughput), focusing on the study focus on genomics, genetics, epigenetics, epigenome human .. Experience in online teaching and the creation and organization of courses. English: Bioinformatician/Molecular Biologist specialist - design and/or implement innovative algorithms and statistical packages for high throughput data analysis, focus on human genomics/genetics/epigenomics/epigenetics. See publication list at PubMed (http://goo.gl/jfWEY) Instruction - designed and administrated molecular biology courses/workshops with laboratory; attended and participated at international scientific meeting such as Diabetes (USA), Endocrinology (Brazil), Society of Developmental Biology (USA), American Association for Cancer Research, The Cancer Genome Atlas (TCGA) conferences. Specialties Bioinformatics: R statistical packages, Bioconductor, Perl, Bioperl, SQL, and functional in other computer programing applications to assist in biological discovery. Molecular Biology: Genetic engineering such as cloning, genetic mutation; DNA/RNA/Protein extractions and visualization techniques such as RT-PCR, qPCR, northern, southern, western; siRNA/shRNA constructs; retrovirus/lentivirus production for efficient delivery of gene of interest; Human cell culture. (Source: Lattes Curriculum)
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Genomic and epigenomic features in coding and non-coding DNA have recently been uncovered through advancements in DNA sequencing technologies. Large multi-national consortia (The Cancer Genome Atlas (TCGA), NIH Roadmap and ENCODE) who have spent millions of US dollars in hopes to advance our understanding of human genome across commonly used research cell-lines (e.g. MCF-7, HMEC, etc.), p…
DNA methylation is a process involved in gene stability, genomic organization and developmental process and has being associated with many diseases, such as cancer. In cancer, a genome-wide hypomethylation at non-promoters and focal hypermethylation at given CpG islands (promoters) are observed, responsible for overexpression of oncogenes and silencing of tumor suppressor genes, respectiv…
Cancer, which is one of the major causes of mortality worldwide, is a complex disease orchestrated by aberrant genomic and epigenomic changes that can modify gene regulatory circuits and cellular identity. Emerging evidence obtained through high-throughput genomic data deposited within the public TCGA international consortium suggests that one in ten cancer patients would be more accurate…
Gliomas, including glioblastoma which is the most lethal intracranial tumor, exhibit a very complex development that can lead to treatment resistance and recurrences. This heterogeneity can interfere in the diagnosis and, therefore, in the therapeutic approach. Currently, gliomas are classified based on histology and then graded on a scale of I to IV, depending on the degree of malignancy…
(Only some records are available in English at this moment)
Cancer cells are marked by deregulation of gene expression and genomic instability attributed to genetic mutations and epigenetic alterations that determine active and repressed chromatin. Among the epigenetic modifications, DNA methylation deregulation is a hallmark in cancer. Non-tumoral cells present genome-wide methylation, and hypomethylation in CpG islands (CGIs). In contrast, some …
Malignant gliomas are quite heterogeneous brain tumors characterized by progression and recurrence with highly variable patterns and intervals. The World Health Organization established both histological and molecular features to classify gliomas in 2016, being IDH mutation the most predictive biomarker. So far, this alteration was associated with favorable clinical outcome and increased …
Harmful and damaging effects on global chromatin and epigenomic pattern, gene expression, and cellular phenotype has been known to be associated with cancer. The post genome-wide association studies era offers a blueprint for investigating genomics, epigenomics, and transcriptomics information together, providing us an exciting opportunity to enlighten how complex diseases develop at the …
(Only some records are available in English at this moment)
| 4 / 2 | Completed research grants |
| 10 / 8 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 19 / 15 | All research grants and scholarships |
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