graduation at Licenciatura e Bacharelado em Química from Faculdades Oswaldo Cruz (1978), master's at Biochemistry from Universidade Federal de São Paulo (1981) and doctorate at Biochemistry from Universidade Federal de São Paulo (1988). Has experience in Biochemistry, focusing on Biochemistry, acting on the following subjects: kallikrein, proteinase inhibitors, kunitz, kunitz inhibitor and leguminosae. (Source: Lattes Curriculum)
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razilian flora is considered an important source of natural products that may be beneficial to all mankind. Studies of these resources require a concerted effort of the Brazilian scientific institutions. Our research group has been conducting comparative studies of protease inhibitors from leguminose seeds, determining the primary, secondary and tertiary structures, as well as modeling of…
Brazilian flora is considered an important source of natural products that may be beneficial to all mankind. Studies of these resources require a concerted effort of the Brazilian scientific institutions. Our research group has been conducting comparative studies of protease inhibitors from leguminous seeds, determining the primary, secondary and tertiary structures, as well as modeling o…
Cardiovascular disease is a diverse family of diseases encompassing heart attacks and strokes which collectively account for the single major cause of morbidity worldwide with an urgent need for new medicines. As an example, Ischemic stroke is a devastating disease that represents the primary reason for sustained disability and the second leading cause of death worldwide. The holy grail o…
Proteins obtained from seeds of Brazilian plants with inhibitory function on different classes of proteolytic enzymes, on coagulation factors and fibrinolysis, on platelet aggregation were characterized. The inhibitors of coagulation factors and antagonists of platelet activation can be considered for the development of anti-thrombotic drugs. Others inhibit the adhesion of tumor cells to …
(Only some records are available in English at this moment)
The term glioblastoma refers to astrocytoma with the highest level of malignancy (grade IV), and even though its incidence is low when compared to other malignant tumors, it is one of the most lethal human tumors, with only a 12-15 months period of survival. These tumors can be classified according to the existence of a pre-lesion, such as secondary glioblastomas, which develop from lower…
Breast Cancer is characterized by uncontrolled and atypical proliferation of breast cells and can occur in both men and women, although it is less frequent in males. It is cancer that most affects women around the world, especially before the age of 40 in pre-menopause. There are three groups into which breast cancer can be classified: positive for estrogen (ER) or progesterone (PR) recep…
Studies with the bifunctional protein CrataBL have shown that this protein prolongs the partially active thromboplastin test time (aPTT) by influencing the intrinsic coagulation pathway, and in addition it inhibits the effect of heparin on the same pathway suggesting that the interaction of CrataBL with Heparin neutralizes its anticoagulant effects. Contrary to the action of heparin, Crat…
(Only some records are available in English at this moment)
Cancer is a disease that still leads to death in many countries, with the incidence > 90% of the mortality attributable to metastases (Valastyan & Weinberg, 2011). In Brazil, the estimates for 2014 point to the occurrence of 576,000 new cases of cancer. Breast cancer, the most frequent type of this disease in women, has very high mortality rate (INCA, 2014). The 60 cancer cell lines (NCI-…
| 2 / 2 | Ongoing research grants |
| 13 / 9 | Completed research grants |
| 22 / 13 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 39 / 25 | All research grants and scholarships |
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CV Lattes
ORCID