Luciane Alarcão Dias-Melicio

• Abstract

  Paracoccidioidomycosis is a systemic mycosis whose etiological agents are the fungi of the S1 (Paracoccidioides brasiliensis), PS2 (Paracoccidioides americana), PS3 (Paracoccidioides restrepiensis), PS4 (Paracoccidioides venezuelensis) and Paracoccidioides lutzii, all belonging to the Paracoccidioides spp. It´s an endemic disease in Latin American countries, its distribution is heterogene…

  Identification and purification of DNAse produced by fungi of the Paracoccidioides spp complex and their action on NETs (Neutrophil Extracellular Traps) released by human neutrophils in response to the fungus, AP.R

• Abstract

  Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects. To explore the role of IL-18 in inflammatory innate immune responses, we investigated its impact on expression of two toll-like receptors (TLR2 and TLR4) and mannose receptor (MR) by human peripheral blood monocytes, and it…

  Interleukin (IL)-18 increases TLR4 and mannose receptor expression and modulates cytokine production in human monocytes, PUB.ART

• Abstract

  In paracoccidioidomycosis are few studies that evaluated the mechanisms involved in the interaction of Paracoccidioides brasiliensis with human phagocytic cells that culminate in the development of effector and modulator mechanisms in response against this fungus. In this context, in recent years, works in paracoccidioidomycosis have focused the role of neutrophils (PMNs), since the liter…

  Neutrophil extracellular traps identification in lesions of patients with paracoccidioidomycosis, AP.R

(Only some records are available in English at this moment)

• Abstract

  Hidradenitis Suppurativa (HS) is a chronic suppurative cutaneous inflammatory disease characterized by perifollicular inflammation especially in areas of skin folds (e.g, armpits and perineum). With the progression of inflammation, cytokine levels are increased, accompanied by an influx of neutrophils, monocytes and mast cells. Neutrophils exert tissue activity from phagocytosis, discharg…

  Identification of neutrophil extracellular traps (NETs) in lesions of patients with hidradenitis suppurativa and in vitro evaluation of neutrophils: correlation of NETs with disease severity, BP.IC

• Abstract

  The fungus Paracoccidioides brasiliensis is one of the causative agents of the paracoccidioidomycosis (PCM) disease, endemic in regions of Latin America, when its infecting form, formed by conidia or mycelial propagules, is inhaled or inoculated through trauma in the host's skin. Once inside the host organism, the fungus induces an initial immune response with the predominant action of ne…

  Participation of Paracoccidioides brasiliensis GP43 in the induction of extracellular traps by human neutrophils and monocytes, BP.IC

• Abstract

  The paracoccidioidiomycosis (PCM) is a systemic disease considered endemic in Latin America. Its etiological agentes, fungi of the paracoccidioides complex, can be classified as dimorphic fungi. Its infectant phase is conidios that have restricted geographical habitats. This fungal infection occurs due the inhalation of conidios, which leads to a strong immunological response in the lungs…

  Action of DNase produced by Paracoccidioides Brasiliensis on nets (neutrophil extracellular traps) released by human neutrophils in response to the fungus, BP.MS

(Only some records are available in English at this moment)