Abstract
The revolutionary finding of RNA interference (RNAi) has attracted great attention as a novel approach for treating severe and chronic diseases. RNAi is an evolutionarily conserved process by which small interfering RNA (siRNA) induces sequence-specific, post-transcriptional gene silencing. siRNA consists of 21-23 nucleotides (nt) double stranded RNA segments with 3-end overhangs of 2 nt …