bachelor's at Ciências Biológicas (Licenciatura) from Universidade de São Paulo (2004), bachelor's at Ciências Biológicas (Bacharelado) from Universidade de São Paulo (2004) and doctorate at Genetics from Universidade de São Paulo (2009). Has experience in Biochemistry, focusing on Biochemistry (Source: Lattes Curriculum)
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Despite diagnostic and therapeutic advances in the last decades, cancer is still one of the deadliest diseases around the world. The lack of a cure for cancer reflects the complexity of its molecular bases, where the deregulation of cellular metabolic pathways is considered one of the emerging hallmarks of the disease. Therefore, there is currently a great demand for a better understandin…
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), like SARS-CoV from 2003 and MERS-CoV from 2012, is part of the Betacoronavirus genus of the Nidovirales order and is currently the virus that causes the pandemic called COVID- 19 (Coronavirus disease 2019). SARS-CoV-2 causes an acute respiratory disease or SARS, characterized by fever, cough, fatigue and severe cases of pneumon…
In the last years, the number of obese people has increased worldwidely, which also leads to an increase of a number of diseases associated with obesity such as diabetes type II, coronary artery disease, cerebrovascular accident, osteo-degenerative diseases and cancer. Therefore, there is currently a great demand for a better understanding of the biochemical and metabolic processes relate…
According to the National Cancer Institute (INCA) breast cancer is the most common cancer among women in the world; in 2020, 2.3 million new cases were estimated. Regarding treatment, it is known that the use of PARP1 inhibitors (Poly (ADP-ribose) Polymerase 1) for individuals with a BRCA1/2 mutation is a relevant therapeutic strategy based on synthetic lethality. S6K1/2 proteins mediate …
A new outbreak of lung disease caused by a new Coronavirus appeared in Wuhan (capital of the province of Hubei in China) in December 2019 and has spread to different parts of the world, which has prompted the World Health Organization to confirm the outbreak as a pandemic on March 11, 2020. The new coronavirus SARS-CoV-2 genome is composed of a single-stranded positive-sense RNA (+ ssRNA)…
PARP-1 is a protein involved in DNA repair, DNA replication, transcription, genome organization and apoptosis. Once activated by DNA damage, PARP proteins are able to post-translation- modify proteins in a process called parylation, using NAD+ as substrate. Several studies have proved the feasibility of the use of PARP inhibitors as adjuvant chemotherapeutic agents for the treatment of Ca…
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LKB1 is an important upstream inhibitor of the mTOR/S6Ks pathway. Loss of LKB1 is often associated with cancer, including in A549 lung cancer cell line, boosting the transformation of pre-malignant neoplasic cells. Metformin, a natural compound derived from Galega officinalis, is mainly used as a treatment for diabetes mellitus type 2 (DM2), but recently, it has been associated to lower i…
SARS-CoV-2 causes COVID19, characterized by fever, cough, fatigue, and severe cases of pneumonia, having affected more than 10 million people worldwide so far. Three of the virus' structural proteins, proteins E, M, and N, are responsible for the viral particle assembly, among other processes. Protein N has a high affinity for viral RNA, forming the viral nucleocapsid. The membrane protei…
Nrf2 (Nuclear factor erythroid 2-related factor 2) protein is considered one of the major regulators of oxidative stress and, once activated, triggers important changes in the expression of several genes involved in redox homeostasis, drug and cell metabolism, survival, proliferation, autophagy, proteasome degradation, DNA repair and mitochondrial biology. Several studies describe a preve…
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Genomic instability is a hallmark of cancer characterized by an increased rate of alterations in the genome, which favors tumorigenesis and tumor progression. Luckily, cells have mechanisms such as DNA repair, which respond to the presence of DNA damage and help maintain genomic integrity and stability. Recently, the S6K1 protein, a target of mTORC1, has been linked to DNA repair. Particu…
mTOR pathway has been suggested as a central mechanism that converges different signaling pathways to coordinate cell growth and is commonly reported overactivated in cancer. Once activated by growth factors, amino acids, or energy (ATP/AMP ratio), mTOR induces the cap-dependent translation and ribosome biogenesis, increasing protein synthesis and other anabolic processes. mTOR is respons…
Cancer is a pathology characterized by the accumulation of mutations in the DNA of cells, these mutations may be associated with the processes of angiogenesis, inflammation, and tumor innervation. Currently, the process of tumor innervation has been described as a key process for angiogenesis and tumor inflammation. However, the tumor innervation signaling pathways are still unclear. It i…
Obesity has been considered a worldwide epidemic. WHO data are categorical in assert that obesity is responsible for a number of pathologies development, including type II diabetes, cardiovascular disease, stroke, dyslipidemia, osteoarthritis and some cancers. Therefore, there is a great demand for a better understanding of biochemical and metabolic processes related to obesity. The mTOR …
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 21 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 32 / 26 | All research grants and scholarships |
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CV Lattes
ORCID