CV Lattes
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Faculdade de Farmácia e Bioquimica from Universidade de São Paulo (1964), master's at Biochemistry from Universidade Federal de São Paulo (1975) and doctorate at Biochemistry from Universidade Federal de São Paulo (1980). Has experience in Pharmacology, focusing on Pharmacology Molecular Biochemistry, acting on the following subjects: angiotensina ii, receptor at1, bradicinina, angiotensin ii and at1 receptor. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Recent studies have revealed a high structural homology among different receptors with many conserved residues and belonging to the same family, which allow us to predict its structures using a solved structure as a template. The type 1 and type 2 angiotensin II (AngII) receptors (AT1 and AT2 respectively) and type 1 and type 2 kinin receptors (B1 and B2 respectively) belong to the G prot…
Recent study on the structure-activity of the kinin B1 receptor (B1R) revealed that important residues for its binding to des-Arg9-bradykinin (DBK) are homologous to those in the interaction between angiotensin II and the angiotensin II (AngII) type I receptor (AT1R). In addition, as the B1R and AT1R have the same two residues at the C-terminal side (Pro7-Phe8) we hypothesized that both r…
Since we belong to one of the few research groups that not only synthesizes peptides, but has also endeavored to refine this methodology, we have been able to acquire in the last decades, a good level of autonomy in obtaining this relevant class of macromolecules. Peptide analogues have been produced by different strategies, including the use of paramagnetic aminoacids, allowing us good l…
(Only some records are available in English at this moment)
Recent studies on the structure-activity of the kinin B1 receptor (B1R) revealed that important residues for its binding to des-Arg9-bradykinin (DBK) are homologous to those in the interaction between angiotensin II and the angiotensin II (AngII) type I receptor (AT1R). Several studies have shown that the ammonium group of Lys199 (512) located in the helix V of AT1R interacts with the car…
It is known that kinins mediated by constitutively expressed B2 receptor, are important mediators of cardiovascular homeostasis, inflammation and nociception and the inducible B1 receptor, is responsible for the late phase and most serious states of inflammation, that may lead to several pathologies including the sepsis. Then it was of extreme importance the generation of rats overexpress…
Cloning of the kinin B1 and B2 receptors revealed that they belong to the superfamily of seven transmembrane-spanning G protein coupled receptors. The B2 receptor is expressed in almost all cell types and several pharmacological studies have led to synthesis of a series of antagonists displaying high affinity for this type of receptor. The B1 receptor is less studied and is generally abs…
(Only some records are available in English at this moment)
| 9 / 6 | Completed research grants |
| 10 / 6 | Completed scholarships in Brazil |
| 19 / 12 | All research grants and scholarships |
| Associated processes | |