Graduated in Pharmacy-Biochemistry from the Faculty of Pharmaceutical Sciences from the Pontifical Catholic University of Campinas, masters and doctorate in Pharmacy (Clinical Analysis) from the University of São Paulo and postdoctoral from the University of Oxford (UK). She worked as a Scientific Researcher at the Adolfo Lutz Institute (1987 to July, 1990) and as an Associate Professor at the Faculty of Pharmaceutical Sciences, Department of Clinical and Toxicological Analysis, University of São Paulo (July 1999 to November 2018). most important are micronutrient deficiencies and overloads (iron, vitamin B12 and folate) .She has expertise in hematology, population nutrition, biostatistics, nutrigenetics and pharmacogenetics. She is advisor in the Graduate Programs in Clinical Analysis of the Faculty of Pharmaceutical Sciences of the University of São Paulo, the Graduate Program of the Discipline of Hematology and Hemotherapy, Department of Clinical and Experimental Oncology, Federal University of São Paulo, and visiting advisor. Pharmaceutical Sciences Program of FACFAN / UFMS. She is currently a visiting professor at the Faculty of Pharmaceutical Sciences, Food and Nutrition (FACFAN) at the Federal University of Mato Grosso do Sul (UFMS) since September 1, 2019. (Source: Lattes Curriculum)
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In Brazil, most folic acid (FA)-containing drugs are manufactured at dosage of 5 mg. Besides Ministry of Health recommend daily use of this dosage for healthy childbearing women planning pregnancy, it contradicts a World Health Organization guidance, which recommend only 400 µg daily use. Consumption of high amounts of FA by Brazilian people worries us, since it has been associated with a…
Folic acid is a vitamin of B complex which plays an important role in several reactions in the body. Its deficiency produces several clinical complications, such as anemia, increase in cancer risk and cardiovascular disease, defects in neural tube formation, among others. However, with the onset of wheat and corn flour fortification with folic acid in Brazil, since 2004, the population be…
Angiogenesis plays an important role in primary myelofibrosis (MFP) and essential thrombocythemia (TE), wich is mainly modulated by transforming growth factor (TGF)-B1, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor. The aim of this study is to investigate the effect of the mRNA expression of the Smad family (Smad1 to Smad8/9) and microRNAs (miR-193a-5p, miR-…
(Only some records are available in English at this moment)
Folic acid (FA) has been prescribed in Brazil, at a concentration of 5 mg / day for patients with hemolytic anemias, for women who wish to become pregnant and also for women with a history of fetuses with defects of the neural tube (DFTNs). Furthermore, FA is also derived from the diet, including fortified foods. The possible consequences of high concentrations of FA in the metabolism of …
Myelofibrosis (MF) is a Myeloproliferative Neoplasm (MPN) Philadelphia negative characterized by fibrosis development in bone marrow, in response to cell proliferation. Discover of JAK2V617F mutation and its relation with MF made possible the development of drugs targeted to the inhibition of JAK2 protein. However, little information is known about the mechanisms involved in inhibitors of…
Chronic myeloid leukemia (CML) is a clonal expansion of the hematopoietic progenitor cell, representing myeloid hyperplasia, leukocytosis, neutrophilia, basophilia and splenomegaly. The Philadelphia chromosome is peculiar on the disease, being the result of the translocation t(9; 22) (q34; q11), leading on the fusion of the ABL and BCR genes. This merger creates a hybrid gene that produce…
(Only some records are available in English at this moment)
Increasing awareness of the significance of public health consequences of insufficient folate intake has led to increased implementation of interventions providing folic acid. This has emphasized the need for an in-depth review of the safety and toxicology of the provision of folic acid through a variety of mechanisms, such as supplementation and fortification, and in a variety of contex…
| 13 / 5 | Completed research grants |
| 13 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 27 / 10 | All research grants and scholarships |
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CV Lattes
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