bachelor's at Bacharelado Em Ciências Biológicas from Universidade de São Paulo (1993), bachelor's at Licenciatura Em Ciências Biológicas from Universidade de São Paulo (1993) and doctorate at Physiology from Universidade de São Paulo (1998). Has experience in Pharmacology, acting on the following subjects: cytotoxicity, ecotoxicologia, citotoxicidade, lytechinus variegatus and atividade antitumoral. (Source: Lattes Curriculum)
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Brazilian marine ecosystems have great strategic importance for the country. Nonetheless, the sustainable use of marine natural resources is still a challenging endeavor. In fact, in many cases we even ignore what are the resources available, in view of the lack of information concerning biodiversity and ecosystems functioning. Thus, this project was conceived for the development of an in…
Breast cancer is the most common malignancy in women globally. In general, 90% of primary and 50% of metastatic breast cancers respond to systemic agents initially but resistance to therapy is common. Tumours develop resistance to DNA-damaging chemotherapeutic agents, in part, due to enhanced DNA repair capacity. Combination therapies that induce DNA damage and disrupt the DNA damage repa…
Breast cancer is the most common malignancy in women globally. In general, 90% of primary and 50% of metastatic breast cancers respond to systemic agents initially but resistance to therapy is common. Tumours develop resistance to DNA-damaging chemotherapeutic agents, in part, due to enhanced DNA repair capacity. Combination therapies that induce DNA damage and disrupt the DNA damage repa…
Pharmaceuticals are considered emerging organic contaminants and concerns on their environmental impact have been raised in the last decades as they have been detected in the environment. Pharmaceuticals enter the aquatic environment mainly due to WWTP effluent discharges or after direct application for veterinary purposes, such as in aquaculture and animal-infection preventing. A commonl…
(Only some records are available in English at this moment)
Cancer is a set of diseases characterized by the abnormal growth of cells in any tissue or organ, and represents the second cause of death in the world. In order to reduce this problem, the search for new antineoplastic drugs is still a major focus of research. In this context, marine natural products play a key role in the discovery of new substances with pharmacological potential, repre…
Seriniquinone (SQ) and its derivatives comprise a group of substances with potent cytotoxic activity, showing selectivity for melanoma cell lines. These substances have presented a novel and distinct mechanism of action when compared to other quinones, through binding to dermcidin (DCD) and triggering autophagocytosis and apoptosis. One of the challenges for the advancement of SQ in the s…
Gliomas are tumors of the Central Nervous System that affect mainly the adult population, imposing a low survival rate, and the most frequent type, Glioblastoma, is characterized by high aggressiveness and a poor prognosis. The search for new therapies is essential in order to bring not only more drug options, but also the possibility of innovative treatments, including new therapeutic ta…
The most aggressive Skin Cancers is Melanoma, which has a high mortality rate and increasing incidence. The BRAFV600E protein ihibitors, the most recurrent mutation in Melanoma, came at the beginning of the decade as promising treatments, however, the high cost, adverse effects and frequent tumor resistance are limiting its therapeutic success. Given this, there is an urgent need to disco…
Melanoma is one of the most aggressive cancers with increasing incidence, therapies that confer resistance and various adverse effects. Novel drugs with different therapeutic targets and mechanisms of action consist in an attempt to overcome these barriers. In this context, seriniquinone (SQ), synthesized by a rare Gram-positive marine bacterium from the genus Serinicoccus, was described …
Antineoplastics is one of the least studied groups concerning environmental impact and represent specific risks to aquatic species due to their mode of action. The questions addressed in the EMPHASIS project are: 1) Do they cause eco-, geno- and cytotoxicity to ZF? 2) What is their bioconcentration potential to ZF? 3) How do they affect the microbiota in ZF? and 4) How antineoplastic expo…
(Only some records are available in English at this moment)
Glioblastomas (GB) are neoplasms of the Central Nervous System characterised by diffusely infiltrative growth, high aggressiveness and poor prognosis, which mainly affect the adult population, imposing low survival rates. The unfolded protein response (UPR) could be an important mechanism that sustains GB cell survival and aggressiveness. Activated by a process related to ER stress, the U…
Melanoma is the one of the most aggressive and refractory type of cancer, with a remarkable ability to adapt to microenvironmental influences. Its high cellular plasticity and consequent acquired resistance is due by genetic and non-genetic mechanisms, resulting in a heterogeneous tumor with a phenotypic cell spectrum. Non-genetic alterations are associated with transcriptional reprogramm…
Ascidians (Tunicata), or sea squirts, are benthic marine invertebrates widely investigated as a source of new chemical structures with pharmacological potential. More than 1000 molecules were described from ascidians so far. However, the production of most of these metabolites was latter attributed to associated-bacteria, which live a syntrophic association with the tunicate. This relatio…
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 15 / 11 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 27 / 23 | All research grants and scholarships |
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CV Lattes
ORCID