Associate Professor in the Pharmacy program at the Faculty of Pharmaceutical Sciences, State University of Campinas (UNICAMP). She graduated in Pharmacy from the Faculty of Pharmaceutical Sciences at São Paulo State University Júlio de Mesquita Filho (UNESP-1994), obtained her masters degree (USP-1997), and completed her Ph.D. (USP-2001) in Pharmacy (Clinical Analysis) at the University of São Paulo. Her research focuses on clinical pharmacy, pharmacotherapy, and pharmacovigilance. In 2018, she received the Merit Award for Pharmacists from CRF/SP (Regional Council of Pharmacy of São Paulo) in recognition of her outstanding contributions to the pharmacy profession, earning her the title of Comendadora. She supervises masters and doctoral students in the graduate programs of Pharmacology, Medical Sciences, and Pharmacy (Source: Lattes Curriculum)
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Lung carcinoma is the main cause of cancer-related morbidity and mortality in the world, with more than 2.2 million of new cases and 1.8 of deaths estimated to 2020. The most common type of lung cancer is the non-small cell lung carcinoma (NSCLC). The treatment strategy in advanced NSCLC has evolved from empirical chemotherapy to a personalized approach based on better histological and mo…
Cisplatin (CDDP) is a highly effective antineoplastic agent, widely used in the treatment of various malignant tumors, including ovary, endometrium, pulmonary, bladder, head and neck, testicular, breast and colorectal cancer. Regarding CDDP-induced toxicity (mainly nephrotoxicity) considerable inter-individual differences have been reported. Several factors must be considered for differen…
Familial hypercholesterolemia (FH) is an autosomal dominant disease with genetic basis not fully understood yet. This study aims to investigate the genomics, epigenomics and pharmacogenomics bases of monogenic and polygenic FH. Patients with FH diagnosed phenotypically will be recruited in six research centers from different regions of Brazil. The methods include: (i) Ultra deep DNA seque…
The most effective treatment for advanced head and neck cancer is concomitant cisplatin and radiotherapy. However, its use is limited due to its toxicities caused by oxidative stress, mainly nephrotoxicity. There is a need to identify new biomarkers of nephrotoxicity. Among the biomarkers studied, we have the microRNAs and oxidized biomolecules. In addition to these possible biomarkers, t…
(Only some records are available in English at this moment)
Pain is one of the most frequently reported symptoms by lung cancer patients. Opioids are frequently used to manage oncological pain. However, there is considerable interindividual variability in the response to opioids, which can result in ineffectiveness or adverse drug reactions (ADRs). This variability can have various causes, including genetic variability in the OPRM1 gene, which enc…
Ovarian cancer is considered the gynecological neoplasm with the highest morbidity, mortality and incidence rates in the country. Due to its asymptomatic behavior in the early stages, the diagnosis of ovarian cancer is usually late; The recommended treatment consists of cytoreductive surgery followed by adjuvant chemotherapy with a platinum analogue and taxane. Although there are favorabl…
Introduction: Postoperative pain (POP) is common, often undertreated, and increases the risk of chronic pain development. Treatment involves the use of opioids for moderate to severe pain, but there is variability in response, partly due to variations in the CYP2D6 gene. Personalized prescription based on pharmacogenetics can optimize POP management, minimizing risks, and increasing effec…
(Only some records are available in English at this moment)
Gynecological tumors, a group of neoplasms that affect the female reproductive system, are one of the main causes of morbidity and mortality among women worldwide. It includes, among other locations, tumors of the ovary, uterine cervix, and endometrium. In advanced stages of the disease, the recommended treatment is cytoreductive surgery, followed by adjuvant chemotherapy with a platinum …
The new coronavirus (SARS-CoV-2), the agent responsible for Coronavirus Disease 2019 (COVID-19), has become the latest worldwide emergency. The dysregulated expression of some microRNAs (miRNAs) can, for example, modulate the transcription and translation of genes related to immunomodulatory factors that may inhibit or potentiate the inflammatory response, which is quite pronounced in sev…
MIR-443B-59 as a potential biomarker for COVID-19's diagnosis of the new coronavirus (SARS-CoV-2), the causative agent of Coronavirus's Disease 2019(COVID-19), has become the most recent worldwide emergency. At this moment, we use our expertise in genetic and epigenetic areas to contribute in a significant way to the context of thesis-CoV-2 pandemic. MicroRNAs (miRNAs) consists of small, …
(Only some records are available in English at this moment)
Cisplatin is a highly effective antineoplastic agent, however, its use is limited due to its adverse reactions, especially nephrotoxicity. Therefore, there is a need to identify nephrotoxicity biomarker molecules, as classical pathological markers have low sensitivity and specificity. Among the biomarkers proposed in recent years, one of the most promising is miRNA. In a recent study carr…
Cisplatin is a highly effective antineoplastic agent, widely used in the treatment of various malignant tumors, in adults and pediatrics. Despite being effective, toxicity can limits its use. Ototoxicity mediated by cisplatin is irreversible and, in children, it is very important because of the impact on their speech-language acquisition development, social-emotional development, and lear…
Tramadol is an analgesic drug indicated for the treatment of pain of moderate to severe intensity. It is a drug largely used for postoperative analgesia in orthopedic surgery, where it is included in the standard prescription protocol as rescue medication for standard programmed analgesia. Tramadol exerts its analgesic action acting synergistically as an opioid agonist and as an inhibitor…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 10 / 8 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 21 / 19 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 41 / 37 | All research grants and scholarships |
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CV Lattes
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