CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate at Faculdade de Ciências Farmacêuticas from Universidade Estadual Paulista Júlio de Mesquita Filho (1994), master's at Pharmacy from Universidade de São Paulo (1997) and ph.d. at Pharmacy from Universidade de São Paulo (2001). Has experience in Biochemistry, focusing on Biochemistry, acting on the following subjects: atherosclerose, hypercholesterolemia, antioxidants, nitrc oxide and ROS. (Source: Lattes Curriculum)
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Cisplatin (CDDP) is a highly effective antineoplastic agent, widely used in the treatment of various malignant tumors, including ovary, endometrium, pulmonary, bladder, head and neck, testicular, breast and colorectal cancer. Regarding CDDP-induced toxicity (mainly nephrotoxicity) considerable inter-individual differences have been reported. Several factors must be considered for differen…
Familial hypercholesterolemia (FH) is an autosomal dominant disease with genetic basis not fully understood yet. This study aims to investigate the genomics, epigenomics and pharmacogenomics bases of monogenic and polygenic FH. Patients with FH diagnosed phenotypically will be recruited in six research centers from different regions of Brazil. The methods include: (i) Ultra deep DNA seque…
The most effective treatment for advanced head and neck cancer is concomitant cisplatin and radiotherapy. However, its use is limited due to its toxicities caused by oxidative stress, mainly nephrotoxicity. There is a need to identify new biomarkers of nephrotoxicity. Among the biomarkers studied, we have the microRNAs and oxidized biomolecules. In addition to these possible biomarkers, t…
Cisplatin is a high-potency anticancer agent; however, it causes significant adverse drug reactions (ADRs). Potential pharmacokinetic markers must be studied to predict or prevent cisplatin-induced ADRs and achieve better prognosis. This study was designed to investigate the relationship between ADRs and kinetics ofcisplatin excretion in the urine of patients undergoing high-dose cisplati…
(Only some records are available in English at this moment)
The new coronavirus (SARS-CoV-2), the agent responsible for Coronavirus Disease 2019 (COVID-19), has become the latest worldwide emergency. The dysregulated expression of some microRNAs (miRNAs) can, for example, modulate the transcription and translation of genes related to immunomodulatory factors that may inhibit or potentiate the inflammatory response, which is quite pronounced in sev…
MIR-443B-59 as a potential biomarker for COVID-19's diagnosis of the new coronavirus (SARS-CoV-2), the causative agent of Coronavirus's Disease 2019(COVID-19), has become the most recent worldwide emergency. At this moment, we use our expertise in genetic and epigenetic areas to contribute in a significant way to the context of thesis-CoV-2 pandemic. MicroRNAs (miRNAs) consists of small, …
Lung cancer is the most prevalent type of cancer in Brazil and has the highest mortality rate. One of the treatments used in lung cancer is chemotherapy, which is applied as a palliative treatment in more advanced cases. Among the chemotherapy protocols, the association of carboplatin with paclitaxel is the most indicated combination, but it has several adverse effects, such as myelosuppr…
(Only some records are available in English at this moment)
Head and neck cancer corresponds to tumors located in the upper aerodigestive tract. The most effective treatment is radiotherapy concomitant with chemotherapy with high doses of cisplatin; however, its use is limited due to its adverse reactions, especially nephrotoxicity. Therefore, there is a need for identification of nephrotoxicity predictor molecules, since classical pathological ma…
Head and neck cancer correspond to tumors located in the upper aerodigestive pathways. The most indicated treatment consists of radiotherapy concomitant with chemotherapy with high doses of cisplatin, but its use is limited due to its toxicities, mainly renal, caused by oxidative stress. There is a need to identify new biomarkers of nephrotoxicity, since traditional markers are poorly sen…
Capecitabine (CAPE), a prodrug of 5-fluorouracil (5-FU), is widely adopted in clinical practice as a chemotherapeutic agent incorporated in the treatment of several malignancies such as colorectal and gastric cancer and is available on SUS. Although it has shown benefits in patient survival, its incidence of serious adverse events are very significant ,mostly gastrointestinal, dermatologi…
(Only some records are available in English at this moment)
Cisplatin is a highly effective antineoplastic agent, however, its use is limited due to its adverse reactions, especially nephrotoxicity. Therefore, there is a need to identify nephrotoxicity biomarker molecules, as classical pathological markers have low sensitivity and specificity. Among the biomarkers proposed in recent years, one of the most promising is miRNA. In a recent study carr…
Cisplatin is a highly effective antineoplastic agent, widely used in the treatment of various malignant tumors, in adults and pediatrics. Despite being effective, toxicity can limits its use. Ototoxicity mediated by cisplatin is irreversible and, in children, it is very important because of the impact on their speech-language acquisition development, social-emotional development, and lear…
Tramadol is an analgesic drug indicated for the treatment of pain of moderate to severe intensity. It is a drug largely used for postoperative analgesia in orthopedic surgery, where it is included in the standard prescription protocol as rescue medication for standard programmed analgesia. Tramadol exerts its analgesic action acting synergistically as an opioid agonist and as an inhibitor…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 16 / 14 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 33 / 30 | All research grants and scholarships |
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