bachelor's at Farmácia Bioquímica from Universidade de São Paulo (1999), master's at Pharmacology from Universidade de São Paulo (2002), doctorate at Pharmacology from Universidade de São Paulo (2006) and doctorate at Estágio sanduíche from National Institute On Aging (2006). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: nf-kb, stress, na,k-atpase, envelhecimento and doença de alzheimer. (Source: Lattes Curriculum)
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Our previous data revealed that the signaling pathways associated with ±-Klotho, glutamate, mediators of the inflammatory response in the central nervous system (CNS) and that related to different isoforms of the Na, K-ATPase (NKA) protein as a pump and receptor for endogenous steroids ( ouabain-like hormones) are associated with neuroplasticity and neuroprotection. This effect induced by…
Although originally described as tumor suppressor, PTEN (phospatase and tensin homolog deleted on chromosome ten), has been studied by researches related to cellular processes such as cell growing, cell proliferation, cell survival, metabolism and cell migration, with a potential modulatory role on neurogenesis, synaptic plasticity and, more recently, inflammation. The location of PTEN in…
PTEN (Phosphatase and tensin homolog on chromosome ten) is known as a tumor suppressor with its roles related or not to its phosphatase activity. Studies have been focused to investigate mechanisms relating PTEN to tumorigenesis. However, due to the broad characteristics of this phosphatase which is able to influence cellular proliferation, survival and migration, PTEN seems also to play …
The modulation of the glutamate activity via NMDA receptor has a strong influence in the adaptive processes that prevent premature aging, as well as play an important role in cognition and degenerative processes. It is well know that the insulin signaling pathways, mediators of the inflammatory response and Na,K-ATPase acting as enzyme and as a receiver of endogenous steroids (hormones wi…
(Only some records are available in English at this moment)
The aging process is characterized by a functional decline of several physiological systems. In the central nervous system, aging may be related to cognitive impairment, as a consequence of changes in synaptic plasticity. Klotho protein is involved in the aging process, participating in some signaling pathways. In the central nervous system, Klotho is synthesized by ependymal cells of the…
Neural progenitor cells are cells with capacity for renewal and differentiation into neurons and glia cells, important cell types in the recomposition of brain tissue. Studies with murine neurospheres deficient in Klotho (a protein that at absent or low levels is associated with damage to cognition, synaptic plasticity, and cell proliferation) have already pointed to affected neurogenesis…
Klotho, a protein encoded by the human KL gene which regulates several physiological processes such as phosphate, calcium and vitamin metabolism. It is known as an aging suppressor protein due to the increased expression associated with increased lifespan. On the other hand, it was demonstrated in literature that Klotho gene deficiency in mouse generates cognitive impairment, oxidative st…
Neuroinflammation, oxidative stress and excitotoxicity are processes strongly linked to aging and central nervous system (CNS) pathologies like Parkinson´s and Alzheimer´s diseases. The recognition of exogenous or endogenous molecular patterns (such as lipopolysaccharide) by specific receptors in innate immune cell membranes triggers inflammation in CNS. This recognition activates microgl…
The increase in life expectancy of the world population creates the need for understanding the aging process. This process induces alterations in organic functions at different levels of biological complexity which are directly related to the appearance of diseases. In the 90s, the discovery of a deletion in the gene that encodes the Klotho protein, in rodents, was shown to drastically de…
The objective of this project is to study the altered signaling pathway of PTEN (phosphatase and tensin homolog deleted on chromosome 10), related to some pathologies of the central nervous system (CNS), such as the Autism Spectrum Disorder (ASD), among others. The attention on ASD has been growing as more research is being made about it, demanding data gathering for improvement attempts …
(Only some records are available in English at this moment)
PTEN, which is essential for embryonic development, is a protein capable of controlling cell growth and proliferation by acting through the PI3K/AKT pathway. Since it has several roles in the development of the central nervous system (CNS), PTEN deletion has been associated with some neurological disorders. In turn, Klotho is a protein associated with longevity that has received increasin…
| 1 / 1 | Ongoing research grants |
| 6 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 10 / 10 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 22 / 21 | All research grants and scholarships |
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CV Lattes
ORCID