Alyne Simões Gonçalves

• Abstract

  Diabetes can lead to dysfunction of the secretory capacity in salivary glands and impairs tissue repair. The low-level laser therapy (LLLT) has been applied clinically for treatment of salivary glands dysfunction as xerostomia and Sjogren's syndrome as well as for wound healing. However, the underlying mechanism of laser therapy action and the dosimetric protocols are poorly studied and l…

  Biomodulation effect of low level laser therapy in diabetes: action mechanism and dosimetry, AP.R

• Abstract

  Oral mucositis and hyposalivation/xerostomia are dose-limited debilitating consequences from antineoplastic treatment. Several literature articles have shown the positive effects from different phototherapy modalities on the treatment of these complications, however, the action mechanism of these phototherapies upon oral mucosa and salivary glands is yet not totally known. Thus, the aim o…

  Comparative study of different phototherapies (LED, high and low power lasers) on oral mucositis and laser effect upon salivary glands hypofunction both induced by 5-fluorouracil in hamsters, AP.R

• Abstract

  Patients submitted to chemotherapy and/or head and neck radiotherapy are usually affected by oral complications, especially oral mucositis and severe pain, which demands support therapy. Although the management of such oral complications by phototherapy with laser (LPT) and with LEDs has been studied, the comparison between these therapies has not been studied yet. Thus, the aim of this…

  Comparative study between LED and laser as phototherapies against chemotherapy-induced oral mucositis, AP.R

• Abstract

  Oral mucositis (OM) is one of the most debilitating side effects of cancer treatment and can be responsible for treatment interruption, increasing patient's morbidity and mortality. The 5-Fluorouracil (5-FU) is an antimetabolic chemotherapy that inhibits cellular mitosis, causing OM. One therapy that has been widely used for the treatment of these lesions is the Photobiomodulation Therapy…

  Influence of different photobiomodulation therapy protocols, in the red wavelength range, upon the modulation of the inflammatory process and repair of oral lesions, induced by 5-FU, in hamsters, BP.IC

• Abstract

  The benefits of low-power photobiostimulation (PBM) are already well known for prevention or treatment of oral mucositis (OM), an inflammatory condition of the oral mucosa caused by conventional chemotherapy and head and neck radiotherapy. Therefore, several options for the application of laser have appeared on the market, such as the simultaneous application of red (660nm) and infrared (…

  The effect of low-power laser on red, infrared wavelengths and their associations in inflammation and classification of oral mucositis induced by 5-FU in hamsters, BP.IC

• Abstract

  This work aims to compare the intensity of tissue repair excisions performed in rats, diabetic and non-diabetic, through the effect of different protocols with low intensity laser, and the variables will be the dose, frequency of the irradiation and the way it will be delivery. 80 rats were randomly divided into two major groups - diabetics and non-diabetics - and in to them, there are 8 …

  Comparative study of different irradiation protocols with low power laser for tissue repair of excisions performed on the back of non-diabetic and diabetic rats induced by streptozotocin, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Wound healing is an intricately orchestrated process. The attainment of perfect healing remains one of the holy grails of the wound repair field, and impaired and aberrant wound healing is a significant clinical problem, affecting approximately 6.5 milion people in the United States. One tissue that nearly always exhibits superior wound healing is the oral mucosa. It has been suggested th…

  Role of microRNA in skin wound healing: effects of low level laser therapy and comparative study with oral mucosa healing, BE.PQ

• Abstract

  Diabetes mellitus causes a series of biochemical and histological changes in the salivary glands of streptozotocin-induced diabetic rats. Furthermore, our group has investigated the effect of laser irradiation upon salivary glands and our data demonstrated that this therapy would be helpfull in cases of hypofunction of the salivary glands and xerostomia. However, the action mechanism of t…

  Effect of laser on calmodulin concentration of parotid glands of diabetic rats, BE.EP.IC