Graduate at Medicina from Universidade Estadual de Londrina (1988), master's at Mental Health from Universidade de São Paulo (1995) and ph.d. at Mental health from Universidade de São Paulo (2000). Has experience in Medicine, focusing on Psychiatry, acting on the following subjects: Emergency Psychiatry and Early Intervention, and Biological and Social Determinants of the Mental Disorders (Source: Lattes Curriculum)
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Tramadol is an atypical opioid with a low potential for abuse and dependence. Although studies have pointed to the beneficial effect of adjuvant therapy with tramadol in post-traumatic and obsessive-compulsive stress disorders, no clinical research has been performed so far in patients with major depressive disorder (MDD). Aim: To evaluate the effectiveness of tramadol (daily dose of 150 …
Mental disorders account for a significant proportion of the global burden of disease. However, estimates of "disability-adjusted life years" and "years of life lost " are underestimated due to a lack of good quality data on mortality associated with mental disorders, especially in middle- and low-income countries. The present project aims to estimate the general mortality and by specific…
Schizophrenia and other psychotic disorders (SOP) are highly prevalent with significant morbidity and mortality. However, data on the incidence and course of SOP across the globe are still scarce, especially in developing countries. The etiology of SOP is multifactorial, involving biological and social factors, and a genuine advance in the understanding SOP depends crucially on an integra…
(Only some records are available in English at this moment)
According to theories of a psychosis continuum, Psychotic-Like Experiences (PLEs) are present in a significant proportion of the general population, increasing in 5 to 16 times the future risk of transiting toward a schizophrenia-spectrum disorder. Growing body of evidence suggests a role of the immune system in psychosis; hitherto, little is known about alterations of inflammatory marker…
Cannabis use and childhood trauma associated with a genetic predisposition may increase the risk of psychosis. Genetic variations in N-methyl-d-aspartate (NMDAR) and Cannabinoid type 1 (CB1) receptor genes have contributed to the development of psychoses. However, the neurobiological processes underlying this relationship (cannabis use, childhood trauma and variants of NMDAR and CB1 genes…
Schizophrenia and other psychotic disorders are a serious public health problem with high morbidity and mortality (McGrath et al. Epidemiol Rev 2008,30:67-76). The few studies conducted in low- or middle-income countries and/or located in the southern hemisphere, although methodologically very heterogeneous, contradict the belief that the evolution and prognosis of psychoses would be more…
Depressive episodes during gestation and the postpartum period are highly prevalent, especially in low- and middle-income countries, with serious consequences for the mother-baby binomial (Gelaye et al., Lancet Psychiatry, 2016; 3 (10): 973- 982). Suicide rates during the postnatal period are similar to those observed in other phases of the female life cycle, which speak against the commo…
(Only some records are available in English at this moment)
Weight gain is a critical issue in patients with psychosis, mainly associated with antipsychotic treatment. Preclinical models showed that antipsychotic treatment induces weight gain providing evidence for the metabolic side effects of antipsychotics. However, if the rapid weight gain seen in most patients on newly initiated antipsychotics is determined by epigenetic factors is not clear,…
Background. We and others have identified signs of immune dysregulation in patients with psychosis relative to community-based controls. Interleukin (IL)-6 stands out as the most consistently raised cytokine in the liquor and blood of patients, including evidence in drug-naïve patients. Although adjunctive anti-inflammatory treatments in psychosis are promising, these have yielded mixed r…
Epidemiological studies strongly suggest an association between childhood maltreatment and psychosis, and that the cessation of traumatic experiences may reduce the incidence of psychosis by 33%. Recent investigations started to suggest inflammatory cytokine dysfunction in psychosis, and that childhood adversity may underlie this relationship. Despite of that, only two clinical studies ha…
Schizophrenia is characterized by disturbances originate in neuronal development and a subtle brain pathology in which deficits in specific GABAergic and glutamatergic neuronal subtypes are apparent. This is demonstrated by decreases in markers of GABAergic neuronal functions, such as expression of the synthesising enzyme glutamic acid decarboxylase (GAD) and parvalbumin (PV), a protein p…
| 4 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 3 | Completed scholarships abroad |
| 19 / 17 | All research grants and scholarships |
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CV Lattes
ORCID