CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate in Pharmacy and Biochemistry at Faculty of Pharmaceutical Sciences, University of São Paulo (2001), Visit fellow at the University of California, UCSD (2005), PhD at Pharmacology by the Institute of Biomedical Sciences, University of São Paulo - ICB/USP (2002-2006) and postdoctoral fellow at Department of Immunology, ICB/USP (2006-2010). Researcher at Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden (2010-2011). He is currently position as an Assistant Professor at Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo (FBC/FCF/USP). He has experience in Immunology and Cellular Biology, focus on the following subjects: insulin, cytokines, inflammation, signaling pathways and cellular immunology. (Source: Lattes Curriculum)
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Obesity is a chronic metabolic disease that may be associated with physiological disorders, such as diabetes mellitus (DM) and hypertension (HTN). Some studies have shown common pathways linking obesity and diabetes to insulin resistance and the renin-angiotensin system (RAS), a leading regulator of blood pressure. Angiotensinogen (Agt) is the main precursor of RAS. Activation of Agt in a…
Obesity is a complex disease that increases mortality and associated comorbities such as diabetes and cardiovascular diseases. One of the critical pathways involved in obesity is the Renin Angiotensin System (RAS) which is classically known to regulate blood pressure and fluid balance is also expressed in adipose tissue. RAS contributes to inflammation in obesity and diabetes and is often…
Asthma is a complex disease that simultaneously involves the participation of several cells, cytokines and inflammatory mediators on which the initial phase is completely different from the late stage. In previous work, we used an experimental omdel developen in mice pre-immunized with ovalbumin (OVA) and found that insulin interferes with the production/release of cytokines, cell migrati…
Diabetic subjects are more susceptible to infections, which is at least partially due to insulin deficiency and hyperglycemia. We hypothesized that insulin influences cytokine release by macrophages stimulated with lipopolysaccharides (LPS) in diabetic C57BL/6 mice. Using bone marrow-derived macrophages (BMDM) from diabetic mice, we showed that LPS induced an increase in TNF-± and IL-6 re…
(Only some records are available in English at this moment)
Aging is a natural and multifactorial process obtained by the gradual loss of physiological integrity. In this context, autophagy, a process of intracellular content degradation, naturally regulated by the rapamycin target nutrient sensing receptor (mTOR) or chemically by the drug rapamycin (RAPA), has a direct relationship with cellular homeostasis and maintenance of the senescent phenot…
Autophagy is an essential metabolic pathway for cellular homeostasis process, which Perform a constitutive and active function in controlling the biosynthesis of proteins and organelles, furthermore, it is a genetically regulated and conserved cellular process. This pathway is naturally regulated by the nutrient sensing receptor denominated the mechanistic target of Rapamycin (mTOR) or ch…
Hyperglycemia is the main characteristic of diabetes mellitus (DM) and is associated with high mortality in affected individuals. In previous studies, we evaluated phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB, or Akt) and mitogen-activated protein kinase (MAPK) proteins in bone marrow-derived macrophages (BMDM) after lipopolysaccharide (LPS) stimulation, treated or not with…
Obesity is a chronic metabolic disease that may be associated with various medical disorders including, for example, Diabetes Mellitus (DM) and Hypertension (HTN). Some studies have shown common pathways linking obesity and diabetes to insulin resistance and the Renin-Angiotensin System (RAS),regulator of blood pressure. Angiotensinogen (Agt) is the main precursor of RAS, with angiotensin…
Introduction: In clinical situations, partial hepatectomy (PH) under ischaemia-reperfusion (I/R) is usually performed to control bleeding during parenchymal dissection. Diabetes is particularly associated with poor prognosis of ischemia reperfusion (I/R) injury. It is well known that I/R significantly reduces liver regeneration after hepatectomy. Fibroblast growth factor 21 (FGF21) is mem…
Vitamin D is a steroid hormone synthesized in the skin, which is involved in many physiological processes (homeostasis of phosphorus and calcium, modulation of the immune system) and pathological (autoimmune diseases such as type 1 diabetes mellitus). This disease is characterized by destruction of beta cells through the action of pancreatic B lymphocytes, macrophages, T cells, CD4 + and …
(Only some records are available in English at this moment)
Obesity is a chronic metabolic disease that may be associated with physiological disorders, such as diabetes mellitus (DM) and hypertension. Studies have shown common pathways linking obesity to insulin resistance and the renin-angiotensin system (RAS). Angiotensinogen (Agt) is the main precursor of RAS. Activation of Agt is often linked to dysfunctions in cellular processes, such as auto…
Introduction: In clinical condition, partial hepatectomy (PH) under ischemia-reperfusion (I/R) is commonly accomplished to control bleeding during hepatic resection. It is well known that I/R significantly reduces liver regeneration after hepatectomy. Diabetes mellitus (DM) is particularly associated with poor prognosis of I/R injury. Fibroblast growth factor 21 (FGF21) has beneficial me…
| 1 / 1 | Ongoing research grants |
| 12 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 11 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 29 / 21 | All research grants and scholarships |
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