CV Lattes
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Universidade de São Paulo (USP). Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
He is a member of the Brazilian Society of Physiology (SBFis), Society for Endocrinology, and International Society of Exercise and Immunology. He is currently Associate Professor at the University of São Paulo (USP) - School of Physical Education and Sport of Ribeirão Preto (EEFERP). He has experience in the evaluation of molecular responses to acute and / or chronic physical exercise in different rodent tissues and in skeletal muscle of human beings with or without chronic diseases. degenerative diseases. (Source: Lattes Curriculum)
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Recently, the World Health Organization classified sarcopenia as a disease, which will allow the establishment of universal clinical guidelines for its diagnosis and treatment. In this sense, the rev-erb-alpha protein is a promising molecular target for the prevention and treatment of sarcopenia, since it plays an essential role in the regulation of autophagy, mitochondrial content, oxida…
Recently, the World Health Organization classified Sarcopenia as a disease, which will allow the establishment of universal clinical guidelines for its diagnosis and treatment. In this sense, the rev-erb-alpha protein is a promising molecular target for the prevention and treatment of Sarcopenia, since it plays an essential role in the regulation of autophagy, mitochondrial content, oxida…
The regulation of food intake and control of energy expenditure occur in the hypothalamus through orexigenic and anorexigenic neurons. Hypothalamic inflammation induced by obesity is associated with resistance to insulin and leptin, which impairs the actions of these hormones in the autophagy pathway, causing hyperphagia and increasing body adiposity. It is known that intermittent fasting…
Dr. Donato Americo Rivas is a Scientist II and Professor of Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA), Tufts University (Boston, USA). Dr. Rivas investigates the role of substrates in cell signaling pathways that control the metabolism and growth of skeletal muscle and how nutrition, aging, and physical exer…
Autophagy is a cellular degradation mechanism that aids in the removal of cytoplasmic contents such as macromolecules and organelles. Currently, Dr. Adelino Sanchez Ramos da Silva is the principal investigator of five projects that are supported by the São Paulo Research Foundation (FAPESP) which aim to evaluate the effects of physical exercise on the autophagy in multiple tissues. The pr…
(Only some records are available in English at this moment)
Aging is associated with a progressive reduction in muscle strength, muscle mass, and physical performance (sarcopenia). Estimates indicate that every 10 years the loss of muscle mass is 8% after age 40 and increases to 15% per decade after age 70. When it comes to muscle strength, the numbers are even more aggressive. An important organelle responsible for muscle maintenance through prot…
A sedentary lifestyle reduces mitochondrial functional integrity and, consequently, an increase in free radicals and reactive species production, leading to the onset of chronic non-communicable diseases. In this sense, the transcription factor PGC-1alfa is a promising molecular target with an essential role in regulating autophagy, mitochondrial content, and oxidative function. However, …
(Only some records are available in English at this moment)
The analysis from the scientific literature regarding the proteins related to rev-erv-alpha revealed important interactions with circadian rhythm markers, such as, CLOCK (clock circadian regulator) and OPHN1 (oligophrenin 1) in the neuronal context, and RORA (RAR related orphan receptor A) and NCOR1 (nuclear receptor corepressor 1) in the transcription context, modulating the expression o…
Inflammation leads to endoplasmic reticulum (ER) stress, as well as the practice of acute (APE) and chronic physical exercise (CPE). However, there are still no data in the literature regarding the functions of TLR4 in ER stress during exercise. Therefore, the aim of the study is to verify the responses of markers of ER stress in TLR4 knockout (KO) mice and wild-type (WT) mice after acute…
Our research group verified that the imbalance between the excess of physical exercise and the adequate period of rest is linked with signals of pathological hypertrophy cardiac, lower phosphorylation of protein AMP-activated protein kinase (AMPK) in tyrosine 172, and higher concentrations of interleukin-6 (IL-6) in serum and cardiac tissue in mice. As known, which the increase in IL-6 is…
(Only some records are available in English at this moment)
Insulin resistance is a major risk factor for type 2 diabetes (T2D) and metabolic syndrome. Environmental factors, such as feeding patterns and physical activity levels, can favor insulin resistance development. However, in some cases, skeletal muscle insulin sensitivity alterations can occur many years before changes in glucose tolerance. In addition, induced pluripotent stem cells (iPSC…
The satellite cells (SCS) or skeletal muscle steam cells are responsible for growth and regeneration of muscle fibers. The SCs are located between the basement membrane and the sarcolemma in muscle fibers. Several signaling pathways regulate SCs proliferation and differentiation. It has been demonstrated that autophagy is involved in the proper function and maintenance of stem cells popul…
Elderly individuals present a reduction in skeletal muscle adaptability in response to resistance exercise. Recently, this anabolic resistance was associated with dysregulation of microRNA expression in skeletal muscle of elderly individuals. Although microRNA expression in skeletal muscle provides important data regarding molecular mechanisms responsible for anabolic resistance and sarco…
Osteoarthritis (OA) is a degenerative chronic disease that induces cartilage degradation and is very common in the knee joint. OA progression occurs due to excess load in the joint as well as systemic or local inflammation. Physical exercise is a commonly used therapy to prevent and treat this illness, attenuating the symptoms, however studies that exhibit controversial results still exis…
| 2 / 2 | Ongoing research grants |
| 17 / 11 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 21 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 51 / 42 | All research grants and scholarships |
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