graduate at Licenciatura Em Ciências Biológicas from Instituto de Biociências Letras E Ciências Exatas (1996), master's at Morphology from Universidade Federal de São Paulo (1999) and ph.d. at Ciências (Morfologia) from Universidade Federal de São Paulo (2005). Has experience in Morphology, focusing on Embryology, acting on the following subjects: microtomia, métodos de coloração, fixação, inclusão em parafina and preparado histológico permanente. (Source: Lattes Curriculum)
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Exposure to stress during development alters brain maturation, leading to different behavioural phenotypes. Although adversities in childhood and adolescence increase the risk for stress-related psychiatric disorders (SRPD) such as anxiety, panic, depression and posttraumatic stress disorder (PTSD), there is significant individual variability in the outcomes, indicating the existence of s…
One of the focuses of our research group has been to investigate the pathophysiological relevance of the anti-inflammatory protein annexin A1 (AnxA1) and its mimetic peptides in different models of inflammation through a combination of histopathological, pharmacological, and ultrastructural analyses. On the other hand, we also seek to identify targets that mediate endogenous anti-inflamma…
Annexin A1 (AnxA1) is a 37 kDa protein capable of regulating various cellular and molecular stages of the inflammatory response and is involved in endogenous mechanisms that are activated to obtain an adequate resolution. In addition, some synthetic peptides derived from the N-terminal domain of AnxA1 mimic the pharmacological property of the total protein, especially its anti-inflammator…
In the last years, the research by our group has been focused the role of proteins with anti and proinflammatory activities, specially the galectins-1, -3 and annexin A1 (ANXA1), using different experimental models of inflammation. Thus, these investigations have been expanded with a dual approach: 1) on one hand, the patho-physiological relevance of these mediators in different models of…
Galectins-1 and -3 (Gal-1 e Gal-3), 14.5 and 29 kDa proteins, respectively, operate as potent endogenous mediators of inflammation by controlling leukocyte transmigration process, release of cytokines and mast cell degranulation, thus contributing to homeostasis of the inflammatory reaction. However, the molecular mechanisms by which these lectins modulate cellular responses, particularly…
(Only some records are available in English at this moment)
Type 1 diabetes (T1D) is a global public health problem, which leads to systemic dysregulations that affect multiple tissues, including serious liver complications. Among liver changes, abnormal deposition of lipid droplets, formation of cytoplasmic and/or nuclear vacuoles, mitochondrial damage, increased production of ROS and death by apoptosis stand out. Patients with DM2 have high plas…
In Brazil, there are currently more than 15.5 million people (20-79 years old) living with diabetes mellitus (DM), ranking sixth among the top 10 countries with the disease. In the kidneys, high circulating glucose levels lead to excessive production of reactive oxygen species (ROS) by mitochondria, generating activation of oxidativestress. Furthermore, the production of ROS is associated…
The complex interaction between intestinal microbiota and inflammation is related to intestinal permeability, indicating that endothelial dysfunction is a primary feature of type 1 diabetes (T1D). The annexin A1 (AnxA1) protein, found in inflamed tissues of the intestinal mucosa, acts in the inflammatory response and in the regulation of intercellular junction proteins, such as ZO-1 and c…
(Only some records are available in English at this moment)
NLRP3 is a cytoplasmic receptor that, when activated, forms a protein complex called inflammasome, consisting of NLRP3, caspase-1 and an adapter protein (ASC), and responsible for acting in the release of IL-1b and IL-18. Thus, the NLRP3 inflammasome participates in the pathogenesis of many diseases, including allergic reactions such as asthma, atopic dermatitis, rhinitis and allergic con…
Citrus pectin is a complex polysaccharide, derived from citrus fruit peels, which can be modified through a specific pH and enzymatic treatment that makes it low molecular weight and easily absorbed in the intestine. Modified citrus pectin (MCP) produces pleiotropic effects, including anti-proliferative, anti-metastatic, and immunomodulatory effects. MCP also antagonizes the effects of th…
Annexin A1 (ANXA1) is an anti-inflammatory and pro-resolving protein in the inflammatory response by controlling the migration of leukocytes, release of pro-inflammatory cytokines, and phagocytosis by macrophages. In addition, ANXA1 regulates the activation of the NLRP3 inflammasome in inflammatory cells, but this relationship has not been explored in cells related to inflammatory bowel d…
(Only some records are available in English at this moment)
Introduction: The human genome encodes 12 annexins, including annexin A1 (AnxA1), knownfor its role in inflammation and immune regulation. Previous research indicates theneuroprotective properties of AnxA1 and its N-terminal peptide, Ac2-26, in promoting a proresolving response in neurological diseases. AnxA1 interacts with the NLRP3 inflammasome(NLRP3), forming a pro-resolution regulator…
Diseases that affect the retina have common triggers, such as oxidative stress, inflammation, and neuronal death in the retina. In the search for new potential therapeutic targets, retinal organoids emerge as a robust and technological platform that can aid in the discovery of new therapies. Annexin A1 (AnxA1) belongs to a family of proteins that bind to membrane phospholipids in a calciu…
| 2 / 2 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 20 / 19 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 40 / 36 | All research grants and scholarships |
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CV Lattes
ORCID