graduate at Farmácia e Bioquímica from Universidade de São Paulo (2004) and ph.d. at Fisiologia e Biofísica from Instituto de Ciências Biomédicas da Universidade de São Paulo (2008). Has experience in Physiology, focusing on Physiology, acting on the following subjects: linfócitos, proliferação celular, ceramida and omega 3. (Source: Lattes Curriculum)
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Peripheral Insulin Resistance (IR) and inflammation follow the development of Type 2 Diabetes Mellitus (DM2), with a high prevalence in obese patients. However, a significant percentage of non-obese individuals present DM2, especially in specific regions. For example, in Brazil, this percentage reaches 10 to 20%, while, in Japan, about 60% of type 2 diabetic patients have no Obesity. The …
In Obesity, there is increased plasma leptin and lymphocyte polarization to Th1 cells accompanied by inhibition of regulatory T cells (Treg). However, the relationship between leptin concentrations and lymphocyte differentiation in humans is not established. The flow of metabolites through the glycolytic pathway correlates with the differentiation of Th0 cells to Th1 and Th17, which have …
Type II diabetes mellitus (T2DM2) is the most prevalent form of diabetes and is related to genetic and environmental factors. The development of obesity has been one of the main causes associated with insulin resistance (IR) and T2DM. However, there is a high number of non-obese patients who present this pathology. The Goto-Kakizaki (GK) rats are an experimental model that develop a well-…
Obesity is characterized by increased adipose tissue that causes more secretion of pro-inflammatory adipokines. This increase of adipocytes and proinflammatory factors leads to chronic inflammation that is associated with an imbalance of the immune system and the appearance of diseases. The increase in plasma leptin in obesity results in the polarization of naive lymphocytes (Th0) to Th1 …
Peripheral insulin resistance (RI) and type 2 Diabetes mellitus (DM2) have a high prevalence in obese patients. However, there is an elevated number of non-obese patients that have DM2. The causes associated with the development of DM2 and the characterization of the immunological response in these cases are not clear. Goto-Kakizaki (GK) rats develop genetically well defined condition of …
Several studies have shown promising effects of compounds present in the Ganoderma lucidum extract on tumor cell growth. However, mechanisms controlled by these compounds are not yet established. The aim of this study is to evaluate the effects of different concentrations of ganoderic acid on intracellular signaling pathways involved in the proliferation of JURKAT cells (Leukemic T lympho…
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The main physiological function of leptin is to signal negative energy balance and decrease energy reserves. In addition to the important function in metabolism, leptin can participate in several processes, including immune response modulation. Lymphocytes express the long form of the leptin receptor (OB-Rb) and, therefore, suffer direct effects from leptin on their functions. The activat…
| 1 / 1 | Ongoing research grants |
| 4 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 13 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 20 / 15 | All research grants and scholarships |
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CV Lattes
ORCID