Abstract
Arthritis induced by the mineral oil pristane (pristane induced arthritis - PIA) in mice selected for high (HIII) and low (LIII) antibody production (Selection III) is a unique model, because 100% of LIII animals develop a severe arthritis resembling rheumatoid arthritis (RA) while HIII are completely resistant. We have identified a QTL (Quantitative trait locus) in chromosome 3 (Prtial),…