Sergio Marangoni

• Abstract

  The snake venoms are a complex functional molecules and manly a protein mixture, which along of the evolution trough of mutations and the natural selection for the species maintenance inside of the micro-evolution it was created a several toxins with a high functional complexity and high structural similarity. These toxins has different pharmacological effects such as neurotoxicity and my…

  Chemical modifications by mass spectrometry from the PLA2 Bbil-TX isolated from the Bothriopsis bilineata venom: 'de novo' sequencing using the merge of different kinds of fragmentation and an overlaping of the peptides from a new PLA2 from B. taeniata, AP.R

• Abstract

  In this article we report a rapid purification method using one step chromatography of SVSP Rombeobin (LMR-47) from Lachesis muta rhombeata venom and its pro-coagulant activities and effects on platelet aggregation. The venom was fractionated by a single chromatographic step in RP-HPLC on a C-8 Discovery® Bio Wide column, showing high degree of molecular homogeneity with molecular mass of…

  Rapid purification, pro-coagulant and platelet aggregating activities of Rhombeobin (LMR-47), a Thrombin-like/gyroxin enzyme from Lachesis muta rhombeata snake venom, PUB.ART

• Abstract

  The snake venom has a mixture of functional molecules can be compared by analogy to a natural laboratory that develops and improves toxins through mutations and natural selection to maintain their species microevolution (defense and food). These toxins affect the prey's physiological system making it become paralyzed (neurotoxycity and myotoxicity) and do not run away from the place of at…

  Chemical modifications of myotoxic PLA2 from Porthidium hyoprora: evaluation of catalytic effect and the myotoxic, neurotoxic and inflammatory activities, AP.R

(Only some records are available in English at this moment)

• Biochemical characterization and study of the pharmacological activi in the junction neuromuscular of an isolated miotoxina from the Bothriopsis bilineata venom, BP.MS

• Abstract

  The snake venom of the family Viperidae is characterized by its rich protein/peptides content, able to interfere in specific stages of the haemostatic system. In general, these components stimulate or they inhibit stages key in the cascade of the clotting, fibrinolises, vascular permeability and platelets function. Venom proteins affecting blood coagulation have been classified in several…

  Structure-function study of Lachesis muta rhombeata venom toxin active in thrombus formation in vivo, BP.PD
• Proteome analysis of schizophrenia human brain tissue from posterior superior temporal gyrus, BP.PD