graduate at Farmácia Bioquímica from Universidade de São Paulo (1993), master's at Pharmacology from Universidade de São Paulo (1996) and ph.d. at Pharmacology from Universidade de São Paulo (2001). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: hipertensão, mineralização dental, ratos espontaneamente hipertensos (shr), reparo alveolar and atenolol. (Source: Lattes Curriculum)
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Previous studies from our laboratory suggest that pregnancy is a favorable physiological condition to reduced blood pressure, vascular reactivity to ±1-adrenergic stimulation and to reestablishment of the endothelial function in spontaneously hypertensive rats (SHR). In pregnant SHR, the increased production and bioavailability of NO, resulting from increased phosphorylation of the PI3K-A…
Hypertensive disorders are the leading causes of maternal death worldwide. Thus it becomes essential to develop research to better understand this condition. Research has shown that in pregnant rats normotensive or hypertensive (SHR) there is a significant decrease in blood pressure in the final period of pregnancy directly associated with reduced sympathetic activity of perivascular mese…
(Only some records are available in English at this moment)
Nitric Oxide (NO) is the major vasodilator molecule in the body and it is synthesized by the NO synthase enzymes, and the isoform III or endothelial (eNOS) is the main responsible for the production of NO in the blood vessels. Increased production of Reactive Oxygen Species (ROS) by oxidative enzymes such as NOX enzymes can lead to oxidative stress and reduce NO bioavailability. We have r…
Oxidative stress is an imbalance between reactive oxygen species (ROS) production by oxidant enzymes, such as NAD(P)H oxidase (NOX) and endogenous antioxidant defenses, and it is associated on development and maintance of hypertension. Oxidative stress favors transcription of nuclear factor erythroid 2-related factor 2 (Nrf-2) that regulates the expression of antioxidant enzymes. Previous…
Previous studies have shown that pregnancy is a favorable physiological condition to reduce blood pressure and vascular reactivity to phenylephrine (PE) and reestablishment of endothelial function in spontaneously hypertensive rats (SHR). Mechanisms that increase NO bioavailability in SHR vessels at the end of pregnancy have been investigated and suggest that endothelial nitric oxide synt…
(Only some records are available in English at this moment)
Sepsis is a syndrome of physiologic, pathologic, and biochemical abnormalities induced by infection. The major cause of morbidity and mortality in sepsis is cardiac dysfunction. During sepsis, histones can be released into the circulation due to extensive inflammation and cellular death. Circulating histone levels are correlated to disease severity and the major mediator of myocardial dys…
| 7 / 5 | Completed research grants |
| 21 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 29 / 21 | All research grants and scholarships |
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CV Lattes
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