bachelor's at Tecnologia Médica from Universidad Austral de Chile (1996), master's at Pharmacy from Universidade de São Paulo (1999) and doctorate at Pharmacy from Universidade de São Paulo (2004). Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: metallo-beta-lactamase, imipenem, brazil, nosocomial infection and klebsiella pneumoniae. (Source: Lattes Curriculum)
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Antimicrobial resistance (AMR) has been considered one of the main threats to the human race in the 21st century. We are facing an unstoppable fast-forward instance of Darwinian adaptation through natural selection, in which microbes are constantly evolving to survive antimicrobials. As part of their natural behavior, they adapt continuously. They will succeed unless we develop effective …
The emergence and spread of drug-resistant bacteria has become a global public health problem that has compromised the effective treatment of an increasing range of infections that affect humans and other animals, also impacting environmental health, and, therefore be addressed as a One Health problem. In this regard, the high prevalence and endemicity of bacterial species such as Escheri…
The antimicrobial resistance among clinically important pathogens is a public health challenge worldwide, which exhibits a dynamic trajectory from the environment to hospital settings and vice versa. In this regard, resistance is not static, as pathogenic multidrug-resistant (MDR) bacteria strains can move among human and animals populations, as well as among diferent ecossystems. On the …
A colistin-resistant Escherichia coli was recovered from a patient with a diabetic foot infection in Brazil. Whole genome analysis revealed that the E. coli isolate belonged to the widespread MLST sequence type ST101, harboring the mcr-1 gene onto an IncX4 plasmid, highly similar to IncX4 plasmids bearing mcr-1 recently identified in Enterobacteriaceae from food, animal and human samples …
(Only some records are available in English at this moment)
Bacterial resistance is a global public health and One Health problem, as it reduces treatment options for infections produced by clinically relevant pathogens. The spread of multidrug-resistant pathogens is not restricted to the hospital environment, extending to anthropogenically polluted aquatic environments, such as hospital sewage. For multidrug-resistant Gram-negative pathogens, new…
The emergence and dissemination of pathogens resistant to multiple antimicrobials is a global public health issue, not confined solely to the hospital environment, but encompassing the imperatives of One Health. This project aims to investigate the presence of critically prioritized bacterial pathogens, as defined by the World Health Organization (WHO), encompassing species of clinical si…
Bacteriocins are ribosomal peptides with highly diverse structures, produced by some bacterial lineages. In the search for therapeutic alternatives against multidrug resistant (MDR) pathogens, the research on bacteriocins has increased in the scientific community, recently incorporating strategies based on genomics, proteomics, and genetic engineering. The biodiversity present in non-impa…
The convergence of hypervirulence and resistance to carbapenems and polymyxins in pathogens considered as priority by the World Health Organization (WHO), such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli has begun to be reported worldwide, posing a major threat to the prognosis and control of healthcare-associated infections (IRAS) and infections prevalent in Vet…
Escherichia coli strains producing ²-lactamase extended spectrum (ES²L) of CTX-M type are endemic in Brazil, prevalent in cases of nosocomial infection and outpatient. Recently, strains producing CTX-M have spread to urban environments and pets and / or production, additionally affecting agribusiness. The versatility and variety of pathogenic or contaminant species as is inherent in its p…
The dissemination of Klebsiella pneumoniae strains showing a multidrug-resistant (MDR) or extreme drug resistance (XDR) profile is a worldwide issue that for countries with a high prevalence of infection it has acquired an endemic character. In Brazil, previous studies have shown that endemic genotypes, within many hospitals in the country, are associated with the production of KPC-2-type…
(Only some records are available in English at this moment)
Klebsiella pneumoniae is recognised as an urgent problem of public health worldwide, where the emergence and dissemination of multidrug-resistant (MDR) lineages has been associated with endemic clones producing hospital outbreaks and community-acquired infections. In this regard, K. pneumoniae clonal complex (CC) 258 (comprising STs 258, 11, 340, 437 and closely related variants) has been…
The emergence and rapid dissemination of the plasmid-mediated mcr-1 gene among colistin-resistant Enterobacteriaceae has created an urgent need to elucidate the mechanisms involved in mcr-1 gene transfer. The increased incidences of the mcr-1 gene and its reports at global scale have revealed the hazard of the plasmid-mediated colistin-resistant in 44 countries, so far. Furthermore, plas…
| 1 / 1 | Ongoing research grants |
| 7 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 14 / 10 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 27 / 22 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID