CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Pharmacist graduated from the Federal University of Rio de Janeiro (1998), I obtained the title of Doctor of Chemistry of Natural Products in 2005 by the same institution in the Nucleus of Natural Products Research (NPPN). I am currently an Associate Professor at the Faculty of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo, developing research projects in the areas of medicinal chemistry and synthesis of heterocycles, exploring diverse targets for the discovery of new bioactive compounds in cancer, infectious diseases and CNS diseases, while expanding the chemical space towards innovation. Former President of the Brazilian Association of Pharmaceutical Sciences (2019-2020), as well as an active member of the IUPAC Drug Discovery and Development Subcommittee. I also act as coordinator of the Post-Graduate Program in Pharmaceutical Sciences of Ribeirão Preto. During my career I have visited several Institutions as visiting Professor/Researcher at Rice University and the University of East Anglia. (Source: Lattes Curriculum)
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Nitrogen-containing heterocycles can be found in several bioactive small molecules, and it is well stablished that heterocyclic structures are very prominent scaffolds for drug-discovery research. Additionally, the availability of organic reactions for different functionalizations is the key factor that may be a limiting factor for the development of new drugs. It is widely accepted that…
Based on the current shortcomings with M. tb. RNAP inhibitors, this project aims to build a collaborative TB drug discovery program, impacting human and scientific capabilities at both FCFRP/USP and H3D at University of Cape Town. Sharing critical scientific skills and capabilities between the University of Cape Town and the University of Sao Paolo will generate a well-established and ful…
This proposal describes the strategies for the synthesis and chemical reactivity studies of heterocycles aiming at the development of a small library of structurally innovative fragments. Furthermore, the proposal approaches fragment-based drug discovery studies toward epigenetic inhibitors. Pyrazole-pyridone, pyrido-pyridone and pyrido-pyridazone will be deeply studied in terms of synthe…
(Only some records are available in English at this moment)
Chagas disease is characterized as a neglected tropical disease, caused by the parasite Trypanosoma cruzi, which affects about 8 million people worldwide. However, despite alarming rates, the treatment consists of only 2 drugs, benznidazole and nifurtimox, which have numerous adverse reactions, high toxicity, and limited efficacy in the chronic phase. Furthermore, given the limited intere…
Depression is a complex affective disorder whose most accepted pharmacological cause is monoamine deficiency. In addition, current neurobiological theories have investigated the involvement of glutamate and GABA in order to find new drugs and better understand the neural bases and the cellular and molecular mechanisms involved, since a considerable number of patients do not respond to cur…
Neglected tropical diseases (NTDs) caused by infectious agents, such as parasites, are endemic to low-income populations, and kill or incapacitate millions of people. These diseases have unacceptable indicators and reduced investments in research, production of medicines and inefficient control. An important parameter in the development of new treatments for NTDs is the study of parasite-…
A serie of imidazopyridine-containing compounds have been synthesized and identified as having potent activity on parasite cultures, low cytotoxicity, excellent metabolic stability, and very good plasma exposure upon oral dosing in mice. Promising two new fused ring tested (imidazo[1,2-a]pyridine and imidazo[1,2-c]pyrimidine), have potential for the development of drugs for the treatment …
Cancer is a disease that has affected thousands of people over the years. Epigenetics studies have shown that the superexpression of the enzyme lysine-specific demethylase 1 (LSD-1) is involved with the development of some types of cancer, as prostate, and bladder cancer. This correlation between LSD-1 and cancer growth and progression made LSD-1 become a potential target to find new ther…
(Only some records are available in English at this moment)
A series of new heterocyclic compounds will be synthesized and tested against both a parasitic panel and MRSA and for cytotoxicity. Knowledge of the molecular target of these phenotypically active compounds will be obtained which will facilitate the next phase of the drug discovery process: target (structure)-based projects against better validated targets, accelerating the subsequent opt…
Heritable changes in gene expression that are not based upon alterations in the DNA sequence are defined as epigenetics. The most common mechanisms of epigenetic regulation are the N-terminal histone tails. In the last years, it became evident that the onset of cancer and its progression may not occur only due to genetic mutations but also because of changes in the patterns of epigenetic …
The fast and efficient development of new drugs have been reached by using modern strategies as the Fragment-Based Drug Discovery (FBDD), which from a screened fragment with low potency, a lead compound is obtained by optimization process. For this, the heteroaromatics compounds highlight as good fragments because of their physicochemical and electronic proprieties. So far, our group has …
Chemical space is quite vast, but considering compounds with molecular weight up to 500 Da the number of possibilities is estimated in approximately 1062 compounds, however, only a small fraction of this space is currently exploited for drug discovery process. Within this possibilities, there are a class of compounds that must to be highlighted, the heterocycles, which are structural comp…
(Only some records are available in English at this moment)
| 6 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 14 / 13 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 27 / 26 | All research grants and scholarships |
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