graduate at Farmácia-Bioquímica from Universidade Estadual Paulista Júlio de Mesquita Filho (2002) and ph.d. at Biotecnologia [Araraquara] from Universidade Estadual Paulista Júlio de Mesquita Filho (2006). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: eif5a, pkc1, zds1, gic1 and mrna metabolism. (Source: Lattes Curriculum)
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The translation factor 5A (eIF5A) is highly conserved in Archaea and eukaryotes and is essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. The functional homolog of eIF5A in bacteria is the EF- P factor. The crystal structure of EF-P bound to 70S ribosome show…
Among plant secondary metabolites, isoprenoids form a large and varied class of compounds with widely differing chemical structures and a variety of biological. Friedelin, a triterpene derived from isoprene, is found in the leaves of some plant species, such as Maytenus ilicifolia. This compound is itself biologically active and is also a precursor of the quinone methides tingenone and pr…
(Only some records are available in English at this moment)
The eukaryotic translation factor 5A (eIF5A) is a highly conserved translation elongation factor in eukaryotes and it is essential for the viability of all organisms tested so far. eIF5A undergoes a specific post-translational modification, called hypusination, which is required for its function in the cell. Hypusination occurs in two steps, involving two different enzymes (deoxy-hypusine…
The ribosome is responsible for catalyzing protein synthesis and is supported by several translation factors at all stages of the process (initiation, elongation, termination, and recycling). Although important differences are observed in the initiation, termination and recycling phases between prokaryotes and eukaryotes, the translation elongation has conserved factors in the three major…
The translation factor 5A (eIF5A) is highly conserved in Archaea and eukaryotes and is essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. The functional homolog of eIF5A in bacteria is the EF- P factor, which also undergoes a modification of lysyl or arginyl-…
(Only some records are available in English at this moment)
The eukaryotic initiation translation factor 5A (eIF5A) is highly conserved in eukaryotes and undergoes a specific post-translational modification, called hypusination. Hypusination is required for eIF5A function in the cell and is only present in eIF5A. Deoxyhypusine synthase (DHPS) catalyzes the first step of this modification in eIF5A. Both DHPS and eIF5A are essential for cell viabili…
The translation factor 5A (eIF5A) is highly conserved in archaea and eukaryotes and is essential for cell viability in all organisms tested so far. eIF5A undergoes a unique post-translational modification which essential for its function, wherein a lysine residue is converted into a hypusine. eIF5A and its functional counterpart in bacteria, EF-P, associate between the peptidyl (P) and th…
The translation factor 5A (eIF5A) is conserved and essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. Although it was initially suggested a function for eIF5A in the translation initiation, eIF5A has been demonstrated to have a role in translation elongation.…
(Only some records are available in English at this moment)
| 6 / 5 | Completed research grants |
| 16 / 7 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 29 / 18 | All research grants and scholarships |
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CV Lattes
ORCID