Rafael Malagoli Rocha

• Abstract

  Vulvar carcinoma is a rare gynecologic tumor whose lack of biological information justifies the necessity of novel biomarker Discovery. These new findings allow the comprehension of the important mechanisms in this type of tumor, such as miRNAs, whose disregulated expression has been proved to be important in several tumorigenesis processes. Aims: Characterize miRNA expression profile in …

  Evaluation of the role of miRNAs in vulvar carcinomas: from tumor expression profile to in vitro studies, AP.R

• Abstract

  Vulvar carcinoma is a rare disease that accounts for less than 3% of all female cancers. In younger women this cancer is closely linked to smoking and HPV infection but the prevalence of vulvar cancer cases occur in women over 50 years by genetic mechanisms that still poorly understood. In the past few years some studies showed genomic alterations in vulvar carcinomas, however none of the…

  Differentially expressed gene assessment in vulvar cancer: validations based in results of comparative genomic hybridization array, AP.R
• Analysis of alterations in the genes VHL and BRF-1 and their clinical importance for clear-cell renal-cell carcinoma, AP.R

(Only some records are available in English at this moment)

• Abstract

  Vulvar squamous cell carcinoma is fourth most common type of gynecological cancer and usually is diagnosed in a stage still amenable to potentially curative treatments, including surgery and/or radiation therapy with or without chemotherapy. However, several patients present metastatic diseaseat diagnosis, among those, 30-50% will relapse and did not respond effectively to treatment. EMT …

  Dual inhibitor of PI3K/mTORC1/2, NVP-BEZ235, as a therapeutic strategy in in vitro and in vivo models with alterations of molecules involved in epithelial-mesenchymal transition of vulvar carcinoma, BP.PD

• Abstract

  Introduction: The epithelial ovarian cancer is the fifth leading cause of cancer death among women. The molecular processes that influence the prognosis of patients with ovarian cancer are not understood, therefore it is necessary to identify molecules that enable the understanding of the molecular mechanisms involved in this type of tumor, such as miRNAs. Although many studies suggest th…

  Identification of microRNAs differentially expressed in serous carcinomas of high-grade patients with different clinical outcomes, BP.DR

• Abstract

  Introduction: Colorectal cancer (CRC) is a neoplasm of epithelial origin and covers tumors of the colon and rectum in men and women. It is a treatable and often curable when in the absence of extension to other organs. However, approximately 50% to 60% of patients diagnosed with CRC will develop metastatic, which are most commonly found in liver and lung. Objective: To evaluate the import…

  Functional and experimental study of protein Mrck-b in colorectal adenocarcinomas with or without metastasis, BP.DR

(Only some records are available in English at this moment)

• Abstract

  Despite the high mortality of ovarian cancer, yet little is known about markers that can help early diagnosis and prediction of therapeutic response of women with high grade serous adenocarcinoma. Some studies have demonstrated the role of miRNAs in the progression of ovarian cancer, the prognosis and the resistance to drugs. In our study we have selected homogeneous samples concerning th…

  Validation and functional studies of differentially expressed miRNAs in high grade serous carcinoma of patients with different clinical developments, BE.EP.DR

• Abstract

  Melanoma accounts for less than 5% of skin cancer cases, but it is the major cause of skin cancer related deaths and its incidence has been increasing over the past decades.More than 50% of melanomas cases present mutations of the BRAF gene, which leads to an increase in BRAF kinase activity and constitutive activation of the MAPK pathway, which are potential targets for development of hi…

  Analysis of cellular signaling dynamic changes in circulating tumor cells as response to therapy in BRAF mutant melanoma patients, BE.EP.DR

• Abstract

  Recent findings obtained in ongoing PhD project have demonstrated that miR-133a has clinical importance in vulva carcinomas, a rare type of gynecological tumor in which lack of biological information becomes strong the need to identify molecules that facilitate the understanding of operating mechanisms in this tumor type, such as microRNAs, which deregulated expression has been demonstrat…

  Design and transfection of microRNAs as a therapeutical strategy in vulvar carcinomas, BE.EP.DR