Sandra Gofinet Pasoto

• Abstract

  No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness. There is also a large inter-individual variability in response to treatments with regard to efficacy and toxicity, and for many drugs, there is also a period of weeks to months to establish its efficacy. Within this context, this project aims to evaluate the i…

  Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, AP.TEM

• Abstract

  Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized primarily by involvement of salivary and lacrimal glands, leading to sicca syndrome. Several organ systems may also be affected. Another striking feature is the production of multiple organ specific and non-organ specific circulating autoantibodies. Among these antibodies, we highlight the anti-Ro (SS-A)/ La (SS-B), p…

  Serum autoantibodies in primary Sjögren's syndrome: study of clinical associations and possible correlations with antibodies to viral antigens (EBV and HTLV-1), AP.R

• Abstract

  The coronavirus disease pandemic 19 (COVID-19) progressed rapidly worldwide, reaching lethality of up to 20% in different regions (Garcia LF, 2020). More severe cases were observed in elderly patients with comorbidities, particularly in those with chronic cardiovascular or respiratory diseases, diabetes and hypertension (Garcia LF, 2020; Emmi G, 2020). Coronavirus infection with severe ac…

  Immunogenicity and safety of Coronavac vaccine in patients with autoimmune rheumatologic diseases: primary Sjörgren syndrome, BP.IC

• Abstract

  Primary Sjögren's Syndrome (pSS) is a chronic systemic inflammatory disease, which mainly affects the lacrimal and salivary glands, leading to sicca syndrome. pSS has a probable autoimmune etiology, with the production of several autoantibodies such as antinuclear antibodies (ANA), anti-Ro/SS-A, anti-La/SS-B, rheumatoid factor (RF) and cryoglobulins. Recently, our group described a high f…

  Analysis of the immune profile of saliva and serum of patients with primary Sjögren's Syndrome, BP.IC

• Abstract

  Primary Sjögren's Syndrome (pSS) is an autoimmune disease characterized by chronic inflammatory infiltration of the salivary and lacrimal glands causing dry eye and mouth. Multiple systemic manifestations can also occur. Hydroxychloroquine (HCQ), an antimalarial immunomodulator, has been used for the treatment of arthralgias, myalgia and constitutional symptoms resulting from pSS. However…

  Analysis of blood hydroxychlorochine levels in patients with primary Sjogren Syndrome and possible correlation with the disease activity, BP.DD

(Only some records are available in English at this moment)