graduation at Medicina from Faculdade de Medicina de Santo Amaro (1975) and doctorate at Patologia from Faculdade de Medicina da USP (1986). Has experience in Medicine, acting on the following subjects: morphometry, lung, electron microscopy, lung cancer and pulmão. (Source: Lattes Curriculum)
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The prevalence and social cost of respiratory diseases such as lung cancer, acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, asthma, silicosis, and pulmonary arterial hypertension are high and some of them have few therapeutic alternatives. The therapy of most of these diseases is based on symptomatic control and not on effective cure. The present proposa…
Lung cancer remains the main cause of cancer deaths in the Brazilian population. Even suspecting that the numbers are under-estimated, this neoplasia occupies a place among the most prevalent. In the last decades, several changes have occurred in diagnosis and treatment of this disease. Better therapeutic results and preventive strategies depend on the constant increase on the knowledge…
Adenocarcinomas represent the most common histologic subtype in most countries, contributing to almost half of cases of lung cancer. How huge sources have been spent on trials involving therapeutic aspects in adenocarcinomas, there is need to develop standard criteria to improve behavior, therapy and prognosis of patients. Important changes begin to occur in the treatment of metastatic di…
(Only some records are available in English at this moment)
The extracellular matrix (ECM) is an essential component in tissues and organs, as it regulates cellular processes throughout the body, being essential during development, tissue repair, and homeostasis. Furthermore, the ECM is responsible for a series of signals that regulate and adjust cellular processes, such as proliferation, cell survival, determination of cell fate, cell migration a…
Malignant Mesothelioma (MM) is a neoplasm with a high mortality rate, a virtually zero survival rate in five years of follow-up, and incidence related to exposure to agents, primarily occupational, such as asbestos. The therapeutic options available are restricted due to identification in advanced, inoperable stages. In the last decade, targeted therapy instruments in other neoplasms, suc…
The measurement of proliferative activity assumes an essential role in the gradation of several neoplasms, especially neuroendocrine ones. As an adjunct and indirect method, immunohistochemistry with Ki-67 estimation has been used ubiquitously in surgical pathology, although the tools to estimate its result are questioned. Several methods have been reported in the literature, from cell to…
Small cell lung carcinoma (NSCLC) accounts for approximately 13% of cases of lung neoplasia, is highly aggressive, frequently metastatic at the time of diagnosis, and rarely is it considered therapeutic surgical resection. Regarding the prognosis, it presents the worst estimated average survival rate in 5 years> 5%. Despite the attempt of many clinical studies in the search for new therap…
(Only some records are available in English at this moment)
Previous studies have shown that the level of hyaluronic acid (HA) in the lung tumor stroma correlates with tumor aggressiveness; supporting the hypothesis that HA promotes cell migration and invasion. The lack of information regarding HA and its relation with lung cancer, in addition to the possible role of this extracellular matrix molecule in the development of neoplasias, encouraged u…
In the proposed project the hypothesis is that myofibroblast differentiation is a key factor in driving fibrosis and its de novo emergence is regulated by a complex mechanism involving transcriptional and epigenetic regulation of gene expression by both local and bone marrow derived cells. Two specific directions are proposed, namely analysis of transcriptional and epigenetic regulation o…
| 1 / 1 | Ongoing research grants |
| 23 / 14 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 82 / 25 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 110 / 44 | All research grants and scholarships |
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CV Lattes
ORCID