doctorate at Immunology from Universidade de São Paulo (1991). Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: citocinas, anticorpos ige, imunologia, alergia and resposta celular. (Source: Lattes Curriculum)
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Pregnancy is considered an active period of operative regulatory mechanisms for fetal development, but inflammatory disorders associated with viral infections may alter its outcome. This project addresses Human Immunodeficiency Virus (HIV) and Zika Virus (ZIKV) infection during pregnancy, both capable of congenital transmission with impact in the public health and do not yet have vaccine …
Adenosine triphosphate (ATP) is a predominantly intracellular molecule that can be released to the extracellular space during cellular activation, tissue stress or damage. Out of the cell, ATP can play a crucial role in immune responses and inflammation. Extracellular ATP can be rapidly converted to ADP, AMP and adenosine by ectonucleotidases, such as CD39 and CD73 that are present in the…
Vitamin A through its active metabolite retinoic acid is able to modulate the immune response and maintain mucosal homeostasis, especially in immunological sites such as the GutAssociated Lymphoid Tissue. The neonatal period is characterized by relative immunological immaturity and increased susceptibility to infections. In addition, the neonate is born with low concentrations of vitamin …
Zika Virus (ZKV) is an emergent flavivirus, transmitted by Aedes mosquitoes, causing a primary infection similar to dengue fever and showing remarkable teratogenic potential, particularly fetal microcephaly. Even though ZKV´s ability to infect different cell types, as epithelial cells, neuronal progenitors and cells from the maternal-fetal interface, indicates that this infection exhibits…
(Only some records are available in English at this moment)
Herpes simplex virus (HSV), type 1 (HSV-1) and type 2 (HSV-2), co-evolved with humans and is present in high frequency in the general population, affecting approximately 190 million people worldwide. In general, with a mild or asymptomatic manifestation, it can cause serious neonatal infections, developing encephalitis and keratitis. Furthermore, neuroinflammation/immunosenescence with th…
Zika virus (ZIKV) infection is an aggravating factor of public health, with high morbidity associated with congenital infection and, to date, there is no vaccine licensed for use. ZIKV infections in pregnant women and cases of congenital ZIKV syndrome remain active, which highlights the need to develop prophylactic vaccine strategies to face this scenario. In this project, we will work wi…
Newborns exposed to HIV-1 but not infected (NB-ENI) show higher morbidity and mortality from infectious diseases. This prognosis is possibly related to immunoactivation caused by chronic maternal infection even in association with antiretroviral therapy (ART). In this project we will investigate the immunological mechanisms involved in the immunocompromise of RN-ENI. In order to explore p…
(Only some records are available in English at this moment)
The new coronavirus-19 disease (COVID-19), caused by the infectious agent SARS-CoV-2 has become a worldwide public health problem. Data from several countries showed that the number of hospitalizations and deaths caused by the disease were higher in men than in women. This can, in part, be explained by sexual dimorphism, differences based on male and female gender that can influence the …
COVID-19, an infectious respiratory disease caused by SARS-CoV-2, has spread on an epidemic scale, infecting more than 62 million people worldwide to date. Virus infection can progress asymptomatically or generate more severe symptoms, influenced by the presence of comorbidities. Lymphopenia in patients affected with COVID-19 according to the severity of the symptom is recurrent, includin…
During the gestational period several regulatory mechanisms are operative to maintain a homeostatic environment and to allow fetal development. In this context, regulatory T lymphocytes (Tregs) are essential for tolerance, avoiding the exacerbation of both placental and systemic inflammatory reactions. Some gestational complications, such as bacterial and viral infections, have been shown…
(Only some records are available in English at this moment)
DNA vaccines are safety and stable gene expression vectors, with easy design of genetic sequences, which allows molecular manipulation to ensure improved immunogenicity. However, naked plasmids present limitations that can compromise their effectiveness. We previously developed an optimized DNA vaccine to Zika virus (ZIKV) consisting of the DNA sequence coding for the viral antigens carri…
Allergy is a common syndrome that affects around around 1 billion people worldwide, with an increasing prevalence. The most common allergic manifestations are allergic rhinitis, atopic dermatitis, food allergy and allergic asthma. Allergy is mainly characterized by a type 2 immune response, with the differentiation of T helper (Th) cells into Th2 and high production of IgE. Although much …
| 1 / 1 | Ongoing research grants |
| 23 / 12 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 48 / 17 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 78 / 36 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID