bachelor's at Medicina from Universidade Estadual de Campinas (1995) and doctorate at Biochemistry from Universidade Federal do Rio de Janeiro (1997). Has experience in Metabolism, Bioenergetics and Neurobiology, acting on the following subjects: cell death, mitochondria, oxidative stress, calcium and mitochondrial permeability transition. (Source: Lattes Curriculum)
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In the last 40 years, it has become evident that mitochondria are involved in many cell functions besides energy conversion, such as the control of cell death via calcium and oxygen and nitrogen reactive species signaling. Elevated levels of calcium in the mitochondrial matrix stimulate the generation of reactive oxygen which promote the opening of an unspecific pore in the inner mitochon…
In addition to be the cell’s powerhouse, mitochondria also contains a cell death machinery. Indeed, after a number of new mitochondrial proteins and modulator metabolites have been discovered, this organelle has emerged as a center of attention in processes of cell signaling, cell injury and cell death. Evidence has been provided that mitochondria comprise one of the main pathways for cel…
Alterations in the energetic metabolism associated with modifications in the offer of nutrients and oxygen, ionic transport, inhibition of components of the transport chain of electrons or increase in the production of reactive oxygen species can lead to cell death. This cell death caused by failures of the energetic metabolism is a possible cause of several disorders, including arteriosc…
Many diseases are related to changes in energy metabolism and impairment of Ca2+, Na+, H+ or K+ homeostasis, reactive oxygen species (ROS) generation or the activation of mitochondrially-controlled cell death. Our project seeks to enhance our comprehension of these diseases, studying energy metabolism in vitro and applying this knowledge toward the understanding of cellular and in vivo mo…
The mitochondrial transmembrane protein NAD(P)+ transhydrogenase (NNT) catalyzes the transfer of a hydride between NAD(H) and NADP(H), coupled with the transport of a proton between the intermembrane space and the mitochondrial matrix. This process can occur in the direction of generation of NADPH or NADH (i.e., direct and reverse reactions). The NADPH generated by NNT activity stands out…
Previous studies have shown that NAD(P)+ transhydrogenase (NNT) is relevant to maintenance of mitochondrial redox balance in mouse brain, especially under physiologically challenging conditions, such as after treatment with a high-fat diet. In this sense, this project aims at study the role of NNT activity in the development of age-related changes in the central nervous system using a mou…
The nicotinamide nucleotide transhydrogenase (NNT) is a transmembrane protein located in the inner mitochondrial membrane that catalyzes the reduction of NADP+ by NADH producing NADPH and NAD+, coupled to the transport of protons from the intermembrane space to the mitochondrial matrix. This protein is expressed in all mammalian and its function is related to the maintenance of mitochondr…
The object of the present project is to evaluate the mitochondrial bioenergetics in human glioma cells (T98G and U87MG), the results will be correlated with the predominant glycolytic metabolism of these cells, even when incubated in the presence of molecular oxygen (Warburg effect). The objectives are I) To evaluate the occurrence of the Warburg effect under our experimental conditions; …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 13 / 6 | Completed scholarships in Brazil |
| 19 / 11 | All research grants and scholarships |
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CV Lattes
ORCID