Carla Fernanda Franco Penteado

• Abstract

  This new Multi-PI thematic project proposal will be conducted by the Red Blood Cell Research Group, which is formed by researchers from the Hemocentro (Blood Center), the Department of Clinical Pathology, School of Medical Sciences and the Molecular Biology and Genetic Engineering Center (CBMEG) at UNICAMP, in collaboration with several Brazilian and international researchers. The new pro…

  Red blood cell disorders: pathophysiology and new therapeutic approaches, AP.TEM
• Clinical, cellular and molecular alterations in hemoglobinopathies and other hereditary hemolytic anemias, AP.TEM
• Increased matriz metalloproteinase-9 levels and activity in sickle cell disease patients., AR.EXT

(Only some records are available in English at this moment)

• Abstract

  The inflammatory process in sickle cell anemia can be more widely investigated using mice that express human genes of ² globin. Using these animal models, it was demonstrated in vivo that both the adhesion of leukocytes to the endothelium as well as the leukocyte adhesion to sickled cells play a direct role in the vaso-occlusion process and suggest that the endothelium activation and the …

  MicroRNAs expression profile and their influence on asthma experimental model in sickle cell transgenic mice, BP.MS

• Abstract

  In sickle cell anemia (SCA), leukocyte plays an important role in the pathophysiology of disease, and leukocyte adhesion may in fact be the initiating event in vaso-occlusive episodes. The neutrophil appears to be the leukocyte that most participates in the vaso-occlusive process, at least in sickle mice, although mononuclear cells and eosinophils probably also contribute. Preliminary res…

  In vivo evaluation of the role of eosinophil in the vaso-occlusion process using sickle cell transgenic mice: Involvement of Rho-quinase pathway, BP.MS

• Abstract

  The mast cells are derived from hematopoietic stem cells and migrate to their target tissues as immature cells. These cells are inflammatory resident in tissues known for the role in allergic hypersensitivity, but were recently implicated in many immune, vascular and sensorial function, including pain. In the last years, the participation of mast cells in chronic inflammatory diseases, li…

  Inflammatory mediators, interaction with eosinophils and tyrosine kinase inhibitors effects on mast cells of sickle cell anemia patients, BP.PD

(Only some records are available in English at this moment)