CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from the Federal University of Rio Grande do Norte, UFRN (1992). He was Army Medical Lieutenant (1993). He did Residency in Internal Medicine at SUS-Hospital Heliópolis (1994) and in Internal Medicine (1995), Endocrinology and Metabology (1996-1998) at Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFESP). Master (CAPES, 2000) and Doctorate (FAPESP, 2004) in Medicine (Clinical Endocrinology) by EPM/UNIFESP. He did a Sandwich Doctorate (PDEE) at the Eccles Institute of Human Genetics, University of Utah (2003). He discovered the genetic basis of Thyrotoxic Periodic Paralysis by identifying genetic variants in a new potassium channel (Kir2.6) in genetically susceptible patients. He did a Postdoc in Developmental Biology at the University of California San Francisco (2004-2006), where he studied FGF signaling in a model of somatic transgenesis. He was co-editor of the Archives of Endocrinology and Metabology (2007-2010) and vice-president of the Department of Basic Endocrinology of the Brazilian Society of Endocrinology and Metabology (SBEM, 2009-2011). He was Deputy Head of the Department of Biochemistry at EPM/UNIFESP (2010-2011). In 2015, he became an Associate Professor of the Discipline of Endocrinology Department of Medicine. He is the chief preceptor of the Adolescent-Adult Transition Endocrinology outpatient clinic at Hospital São Paulo (HSP) / University Hospital (HU) at EPM / UNIFESP. He coordinates research projects in Molecular and Translational Endocrinology, especially in Developmental Sex Differences (DSD) and health promotion for the Intersex population. In March 2017, he created the Center for Studies, Research, Extension, and Assistance to the Trans Person - Professor Roberto Farina (Núcleo TransUnifesp NTU) of which he was coordinator until 2021. Esteve Pró-Dean of Extension and Culture at UNIFESP (2017-2021). He currently coordinates the Human Identification Laboratory (LabIH) at the Center for Forensic Archeology and Anthropology (CAAF) at UNIFESP. He works in the preceptorship of multidisciplinary and transdisciplinary care for Trans and Intersex people in outpatient clinics linked to the HU / HSP. He has been advising students of Young Scientist Initiation, Master in Science, Doctorate, and Postdoctoral supervision, linked to the Programs of Molecular Biology (CAPES 7) and Endocrinology and Metabolism (CAPES 5) at EPM / UNIFESP. He was elected councilor for the University Council of UNIFESP and the Congregation of EPM/UNIFESP (2021-present). CNPq level II scientific productivity scholarship holder. (Source: Lattes Curriculum)
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Multiple Endocrine Neoplasia type 2 (MEN2) is an autosomal dominant genetic syndrome caused by germline mutations in the RET gene and represented by associations of tumors of endocrine origin, among which stands out the high penetration of medullary thyroid carcinoma (MTC). It is a complex and multifaceted disease that requires a multidisciplinary approach. Our group has contributed to th…
Sex determination in humans is established from the balance of signaling pathways that act in parallel and antagonistically. The pro-testicular pathways pass through the SRY gene's activation, which is a trigger factor for forming the testis. Evidence has suggested the existence of a genetic module for ovarian determination, which is probably composed of more than one factor that acts as …
The prevalence of thyroid nodules depends on several factors such as age, population studied, sex and method of evaluation. Due to the use of high-resolution ultrasound, which can detect nodules as small as 2 mm, the prevalence of thyroid nodules has increased, reaching up to 67 %. As a consequence of the increase in the diagnosis of the nodules, we also observed an increased incidence of…
Thyrotoxic periodic paralysis (TPP) is a clinical condition characterized by reversible attacks of muscle weakness associated with thyrotoxicosis and hypokalemia. It is the most frequent cause of acute flaccid paralysis acquired in adults, albeit more prevalent among Asians and Latin American men. The pathophysiology of TPP is still unclear, but some evidences suggest that the TPP raises …
(Only some records are available in English at this moment)
Medullary Thyroid Carcinoma (MTC) is a neuroendocrine tumor originating from thyroid parafollicular cells, also called C cells, which secrete calcitonin. MTC accounts for 5% of thyroid cancers. Most cases of MTC are sporadic, and approximately 30% are associated with a hereditary syndrome called multiple endocrine neoplasia type 2 (MEN2A and MEN2B). In these syndromes, MTC is the most fre…
Thyrotoxic Periodic Paralysis (TPP) is the clinical condition characterized by sudden and reversible loss of muscle strength associated with thyrotoxicosis and hypokalemia. TPP is the most frequent of acquired acute flaccid paralysis in young male and is more prevalent in Asian and Latin American population. We have recently known that TPP is the newest form of endocrine channelopathy co…
Epigenetic modifications are defined as heritable changes in gene expression that are not accompanied by changes in the nucleotide sequence of DNA. The relationship between epigenetic mechanisms and tumorigenesis was first verified through of whole genome hypomethylation in carcinomas. Abnormal methylation appears to play an important role in differentiated thyroid carcinomas derived from…
(Only some records are available in English at this moment)
MTC, a relatively uncommon form of cancer originating from the parafollicular C-cells of the thyroid, accounts for approximately 2-8% of thyroid cancers1. Activating mutations in the RET receptor tyrosine kinase gene are common in MTC, and KRAS or HRAS mutations also occur. Remarkably, in a recent whole exome sequencing study, no other driver mutations were identified recurrently in MTC,…
| 2 / 2 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 7 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 14 / 12 | All research grants and scholarships |
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