CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduated in Physical Education by the Universidade of Ribeirão Preto (1998) Obtained Ph.D. at Physiology Department from University of São Paulo (2004) under the mentorship of Dr Renato Migliorini (1999-2004). Worked as a Research Scholar at the lab of Dr Timothy Bartness in Atlanta GA, USA (2002-2003). Received Post-doctoral training at the Quebec Institute of Cardiology and Pneumology, Quebec, Canada, under supervision of Dr Yves Deshaies (2005-2009). Worked as a Visiting Scientist at the laboratory of Dr David Sabatini at the Whitehead Institute For Biomedical Research associated to the MIT (Massachusetts Institute of Technology), Cambridge, USA (2009-2010). Currrently, work as Associated Professor at the Institute of Biomedical Sciences, University of São Paulo. Has experience in Human Physiology, focusing on neural, hormonal and molecular control of lipids, carbohydrates and protein metabolism and intracellular signaling via mTOR. (Source: Lattes Curriculum)
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Evidence gathered in the last decades suggests that lipotoxicity and inflammation, through still not completed defined molecular mechanisms, are the main factors connecting adipose tissue dysfunction to the development nonalcoholic fatty liver disease (NAFLD), a group of liver diseases that comprises from a simple hepatic steatosis (NAFL) to more severe steatohepatitis (NASH), cirrhosis a…
Evidence gathered in the last decades suggests that lipotoxicity and inflammation, through still not completed defined molecular mechanisms, are the main factors connecting adipose tissue dysfunction to the development nonalcoholic fatty liver disease (NAFLD), a group of liver diseases that comprises from a simple hepatic steatosis (NAFL) to more severe steatohepatitis (NASH), cirrhosis a…
We propose herein to investigate the mechanisms by which n-3 fatty acids protect from obesity and associated metabolic diseases. More specifically, we will investigate in two integrated research programs the mechanisms underlying the pro-energy expenditure (Aim 1) and anti-inflammatory (Aim 2) actions of n-3 fatty acids. In Aim 1, the following processes will be investigated as possible u…
Lipodystrophy comprises a group of diseases characterized by either a partial or a complete reduction in adipose mass that is associated with the development of several metabolic diseases such as insulin resistance, dyslipidemia, hypertension, hepatic steatosis and atherosclerosis, among others. In this proposal, we will investigate in 3 integrated research programs the molecular mechanis…
The exponential growth of obesity worldwide is increasing the prevalence of several chronic diseases commonly associated to excessive adiposity such as type 2 diabetes, hepatic steatosis and some types of cancer. Despite of its major impact worldwide, little is known about the mechanisms that link obesity to the development of its associated chronic diseases. Being obesity a condition cha…
Role of adipose tissue in the development of obesity and associated co-morbidities: investigation of molecular mechanism and search for alternative therapies. The exponential growth of obesity in the world is associated with a marked increase in the prevalence of several morbidities directly associated with excessive adiposity as Type 2 Diabetes (T2D), Metabolic Syndrome (MS), atheroscler…
(Only some records are available in English at this moment)
Non-alcoholic liver disease associated with metabolic dysfunction (MAFLD) is a heterogenous group of diseases that comprise from a simple liver steatosis (NAFL) to more severe conditions such as Steatohepatitis (NASH), Cirrhosis and Hepatocellular Carcinoma (HCC). The PI3K-mTORC2-Akt-mTORC1 signaling pathway is directly involved in the NAFL-NASH-HCC progression and overactivated in 40-50%…
Preliminary results obtained at undergraduated scientific training suggest that constitutive mTORC1 activation induced by Tsc1 deletion in adipocytes increases adipose tissue BCAA oxidation and lipolysis. Considering these findings, in this master proposal, we will test the hypothesis that mTORC1 is a major regulator of adipose tissue BCAAmetabolismo and lipolysis in visceral, subcutaneou…
(Only some records are available in English at this moment)
The exponential growth of obesity worldwide is increasing the prevalence of several chronic diseases commonly associated to excessive adiposity such as type 2 diabetes, hepatic steatosis and some types of cancer. Despite of its major impact worldwide, little is known about the mechanisms that link obesity to the development of its associated chronic diseases. Being obesity a condition cha…
Several lines of evidence suggest that obesity and lipodystrophy share common properties related to the buffering capacity of adipose tissue (AT) to adequately store fat, leading to redistribution and deposition of lipids in skeletal muscle, liver and pancreas (Snel et al., 2012). Since those organs and tissues do not possess the proper enzymatic machinery for fat storage, the local accum…
(Only some records are available in English at this moment)
The central regulators of autophagy are the serine/threonine kinases unc-51 like autophagy activating kinase 1/2 (ULK1 and ULK2) that participate in the onset of the autophagic cellular process. These kinases in addition to initiate the autophagic cascade, seem to have interesting secondary roles in energy metabolism to coordinate the cellular response to starvation, such as increasing gl…
The thiazolidinediones (TZDs) are anti-diabetic drugs whose use in treating type 2 diabetes is limited by adverse side effects. The goal of this proposal is a biochemical investigation into a mechanism that separates the positive metabolic effects of TZDs from their side effects. PPAR³, the molecular target of the TZDs, is a key regulator of systemic insulin sensitivity, adipogenesis, inf…
In this project, we will continue to collect human adipocyte samples and generate RNA-seq and histone modification ChIP-seq libraries to assess genome-wide transcriptional and epigenomic states. We have identified key cis-regulatory elements with altered activity in the IR state and have determined the candidate transcription factors (TFs) that bind them. We will validate the importance …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 6 / 4 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 22 / 19 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 41 / 36 | All research grants and scholarships |
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