He obtained a Bachelor degree in Biology from the Bielefeld University, Germany (1996) and a Master degree in Biology from the Bielefeld University (1999). He performed doctoral studies (PhD) in Biology/Biochemistry at the Bernhard Nocht Institute for Tropical Medicine (2002) and was Wellcome International Postdoctoral Fellow at the Wellcome Trust Biocentre, University of Dundee, UK (2002-2004) as well as Principal Investigator at the Bernhard Nocht Institute for Tropical Medicine (2004-2010). He did Habilitation and Venia-legendi in Zoology at the University of Hamburg, Germany (2007) which was also accredited as Livre-docência from the University of São Paulo (2013). He was "Jovem Pesquisador em Centros Emergentes" at the Institute of Biomedical Sciences, University of São Paulo (ICB-USP), Vice-President (in exercise) for International Affairs, ICB-USP (2014-2017 (-2019)) and is currently Associate Professor for Molecular Parasitology at ICB-USP, Coordenator of the Master (MSc) double degree programme between ICB-USP and University of Münster (WWU), Germany and the PhD double degree propramme between ICB-USP and University of Groningen (RUG), Netherlands, Founder of the "BSL3 Cell Culture Facility for Vector and Animal Research" and Head of the Department of Parasitology, ICB-USP. He has experience in molecular parasitology, biochemistry and cell biology and is working on the vitamin B1 and B6 metabolism in Plasmodium falciparum and Staphylococcus aureus MRSA. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Infectious diseases are a threat to mankind and currently the causative pathogens are spreading geographically due to globalization and developing drug resistance. Current resistance to chemotherapeutics is occurring to almost all pathogens and therefore new drug targets and/or novel modi of drug target efficacy is urgently needed. In this grant application the focus will be drawn on suic…
Infectious diseases are a threat to mankind and currently the causative pathogens are spreading geographically due to globalisation and developing drug resistance. Current resistance to chemotherapeutics is occurring to almost all pathogens and therefore new drug targets and/or novel modi of drug target efficacy is urgently needed. In this grant application the focus will be drawn on suic…
Infectious diseases are a threat to mankind and currently the causative pathogens are spreading geographically due to globalisation and developing drug resistance. Current resistance to chemotherapeutics is occurring to almost all pathogens and therefore new drug targets and/or novel modi of drug target efficacy is urgently needed. In this grant application the focus will be drawn on suic…
(Only some records are available in English at this moment)
In terms of the proposed collaborative research and educational activities the applicants plan to initiate a long term collaboration, particular involving young scientists and PhD students, in distinct research topics covering drug discovery, drug design and drug delivery. The complementary expertise of the applicants and Institutions involved will be first focused and merged to identif…
Infections with methicillin resistant Staphylococcus aureus (MRSA) are a global problem. Besides hospital acquired MRSA, also community associated MRSA strains have emerged that cause skin and soft tissue infections but also life threatening endocarditis and pneumonia. The increasing appearance of multidrug resistants trains urgently requires novel therapeutic approaches in order to keep …
The malaria parasite Plasmodium falciparum possesses organelles such as mitochondrion and the chloroplast-like compartment named apicoplast which is absent in the human host. Interference with metabolic pathways present in the latter one have been proven be lethal for the parasite. During schizogony P. falciparum need to distribute this organelle to the newly generated merozites which req…
(Only some records are available in English at this moment)
The aim of this research project is to evaluate the effect of molecules selected by rational drug design to interfere with SARS-CoV-2 virion production in vitro by targeting the E protein of the virus.The capacity of CoV E protein to form homo-oligomers targeted to the Golgi membrane has been widely described. Recently, this structure forming an ion channel has been attributed to neutrali…
Malaria is a potentially fatal disease caused by protozoa of the genus Plasmodium and mainly by the species falciparum and vivax which is transmitted to humans by the vector Anopheles through the bites of infected female mosquitoes. However, malaria can be prevented and treated. According to the World Health Organization (WHO) in 2018, almost half of the world population was susceptible t…
Infectious diseases are a threat to mankind and currently the causative pathogens are spreading geographically due to globalisation and developing drug resistance. Current resistance to chemotherapeutics is occurring to almost all pathogens and therefore new drug targets and/or novel modi of drug target efficacy is urgently needed. In this grant application the focus will be drawn on suic…
Malaria is a devastating disease in the tropics which includes the sub-Sahara region in Africa as well as the Amazon region of Brazil. Until now a potent vaccine is not available and therefore the treatment of malaria is solely dependent on chemotherapy. Currently the treatment is based on Arteminsin combined therapies (ACT), however first resistance are already occurring in Thailand. Thi…
Protozoan parasites are highly distributed among tropical countries, especially South-America, Sub-Saharan Africa and South-East Asia. Among these parasites, Plasmodium is the causative agent of malaria, the most devastating parasitic disease. Due to inefficient treatments and the fast-developing parasites, the existing drugs are losing efficacy because more and more resistances are occur…
(Only some records are available in English at this moment)
Reversible post-translational modification of proteins by ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) serves an essential regulatory mechanism for fundamental cellular processes such as cell cycle progression, DNA damage repair, nucleocytoplasmic transport, transcription, and chromatin remodelling. Protein modification by small ubiquitin-like modifiers (SUMOs) is mediated by the co…
Nuclear receptors (NRs) are fundamental regulators of several biological processes in which they are controlling the transcription of target genes in eukaryotic cells that are modulated in a ligand-dependent manner. Most ligands bind to a pocket in the interior of the ligand-binding domain. However, there is experimental evidence of the existence of alternative ligand-binding sites on the…
| 5 / 5 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 14 / 14 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 28 / 27 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID