graduation at Ciencias Biologicas from Universidade Federal do Rio de Janeiro (1997), master's at Byophysics from Universidade Federal do Rio de Janeiro (1999) and doctorate at Microbiology from Universidade de São Paulo (2003). Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: reparo de dna, genoma, peroxido de hidrogenio, cana-de-açúcar and transferência horizontal. (Source: Lattes Curriculum)
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| A theory in motion |
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The CEPID B3 is a network with research hubs based in São Paulo (IQ-USP, ICB-USP), Campinas (IB-UNICAMP, IAC), Ribeirão Preto (FCFRP-USP, FMRP-USP) and Rio Claro (UNESP) that will collaborate to carry out cutting edge basic research into molecular mechanisms that are of prime importance to understand bacterial reproduction, multicellular behavior, competition, colonization and interaction…
Proteus mirabilis is a bacterial pathogen primarily involved in urinary tract infections. This bacterial species often carries integrative conjugative elements (ICEs) from the SXT/R391 family. These are responsible for the spread of antimicrobial resistance genes. These elements are large and carry, in addition to resistance genes and those responsible for their excision and conjugation, …
The world population is getting older and older. Unfortunately, this increased life expectancy is generally associated by so-called age-related vascular diseases, such as dementia, heart infarct, and stroke, which profoundly compromise the quality of life of the elderly. Age-related disorders are generally viewed as necessary evil. Our project challenges this dogma, as we propose that the…
The SOS response is a cellular mechanism of protection against genotoxic stress. In addition to regulating the expression of DNA repair genes, this cellular response also induces mutagenesis, because of the regulation of error prone DNA polymerases. Several classes of antimicrobials are inducers of the SOS response, and therefore can accelerate the emergence of mutants in bacterial popula…
The association of Mobile Genetic Elements (MGEs) with the increase in the number of multidrug-resistant bacteria has become increasingly evident, however the biology of the relationship of these elements with their hosts is a complex aspect. Integrative and Conjugative Elements (ICEs) of the SXT/R391 family are MGEs that integrate into the chromosome and disseminate resistance genes main…
Genetic sequencing of Caulobacter crescentus allowed the identification of open reading frames (ORFs) and genes in its genome. Some of these genes are conserved, making it possible to predict their function. On the other hand, others have not yet been adequately characterized, including the operon formed by the genes CCNA_02417 and CCNA_02418, which encodes DNA repair proteins that, toget…
Chromosomal insertion mechanisms are effective for genetic engineering and ideal for DNA integration in situations where plasmid selection is not feasible, such as in vaccine strains or for environmental release. The creation of new mechanisms for gene insertion into the chromosome is important to expand the range of gene expression systems, reach new bacterial species, and also to use di…
(Only some records are available in English at this moment)
Conjugative and integrative elements (ICEs) from the SXT/R391 family are frequently found in bacteria of the genera Vibrio, Proteus and Morganella, among others. These elements often carry antimicrobial resistance genes, considered important agents in the spread of resistance. However, many elements present in Proteus mirabilis lack these genes, but harbor several of unknown function, unr…
Proteus mirabilis is a bacterium that causes catheter-associated urinary tract infections (CAUTIs) that has its clinical importance associated with prolonged catheterizations. Due to its beta-lactam-sensitive nature, the emergence of resistance to this class of antibiotics led to the identification of the integrative conjugative elements (ICEs) of the SXT/R391 family, which carried such r…
(Only some records are available in English at this moment)
Pseudomonas aeruginosa is an important human opportunistic pathogen, responsible for the high mortality rates in patients with cystic fibrosis. This bacterium has great ability to adapt to adverse situations, which facilitates the establishment and persistence of infection. The inappropriate antibiotic therapy and contact with sub-inhibitory concentrations may cause the bacteria to respon…
| 3 / 3 | Ongoing research grants |
| 3 / 1 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 14 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 26 / 21 | All research grants and scholarships |
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CV Lattes
ORCID