bachelor's at Ciencias Biologicas - Modalidade medica from Universidade Federal de São Paulo (2000) and doctorate at Microbiology from Universidade Federal de São Paulo (2005). Has experience in Immunology, focusing on Immunology, acting on the following subjects: células b-1, macrofago, diferenciação, fagocitose and gp43 paracoccidioides brasiliensis. (Source: Lattes Curriculum)
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miRNA deregulation appears in neoplastic conditions, including hematological diseases. Decreased levels of miR-15a/16 are shown in the human Chronic Lymphocytic Leukemia (CLL) and also in disease-murine models, where both present apoptosis-resistant cells with increase in BCL-2 expression, an anti-apoptotic molecule regulated by miR-15a/16. In CLL, failures in apoptosis system correlates …
Senescence is a normal biological process that occurs in all organisms and involve a decline in cell functions. The effects of aging on the immune system affect the production and function of B and T lymphocytes. Besides implications of immunosenescence on the susceptibility to infectious diseases, this also implicates in the increase of hyperproliferative diseases, such as autoimmune dis…
Ikaros is considered an important regulator of lymphoid development and differentiation. Several reports reinforce the hypothesis that Ikaros expression is deregulated in human leukemias. It has been suggest the role of Ikaros in the regulation of the transcription of genes that are involved in the BCR signaling. The absence of Ikaros is in detrimental for activation of BCR signals. The I…
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5+ B cells in lymphoid organs and peripheral blood. The incidence is high in people over 50 years of age and its prognosis is quite diverse, also affecting treatment. Several therapies are currently in use but, in some cases, there may be resistance and disease relapsing, which demands a search for new alternativ…
The appearance of hyperproliferative diseases, such as chronic lymphocytic leukemia (CLL), is directly related to problems in the process of apoptosis of cells as well as to the immunosenescence brought about with the advancing age of an individual. Studies have shown that with age there is an increase in the population of B-1 cells (cell type found in this disease). This leads to the hyp…
Accumulation of mutations and changes in the immune system could happen in aging, for example, due to environmental pressures. It was seen that there is an accumulation of B-1 cells in bone marrow and lymphoid organs of old mice and our group showed that the B-1 cell progenitor (B-1p - Lin-CD45R-CD19+CD93+) population increases in the bone marrow of healthy old C57Bl/6 mice (with 30 weeks…
Chronic lymphatic leukemia (CLL) is a hematopoietic hyperproliferative disease caused by deregulated B-1 cells (CD5+) expansion. Our group demonstrated that CLL cells show dysfunction and altered localization of Ikaros. This protein acts by repressing or activating the gene expression. Ikaros is associated to a protein complex that is able to remodel the chromatin. The major complex that …
Hyperproliferative diseases, such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are possibly related to some disturb in the apoptosis pathway, specifically in B-1a cells (CD5+). These problems result in the accumulation of B-1a cells in lymphoid organs, bone marrow or periphery, as observed in experimental models with old animals. Furthermore, it is known th…
Bruton's tyrosine kinase (BTK) is an enzyme present in B cells and its expression is very important for both development and proliferation of these cells. The engagement of an antigen in the B cell antigen receptor (BCR) triggers a signaling pathway that culminates with the activation of these lymphocytes. In this pathway, BTK phosphorylates several signaling proteins and interacts with p…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 5 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 12 / 7 | Completed scholarships in Brazil |
| 21 / 13 | All research grants and scholarships |
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CV Lattes
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