graduate at Biomedicina from Universidade Federal de São Paulo (1993), master's at Biochemistry from Universidade Federal de São Paulo (1995) and ph.d. at Biochemistry from Universidade Federal de São Paulo (2000). Has experience in Medicine, focusing on Medicine, acting on the following subjects: depuração hepática, bradicinina, fígado, resposta hipertensiva portal and inflamação. (Source: Lattes Curriculum)
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Our research group has been studying the hepatic modulation of kinin system for decades. The kinin system is represented mainly by bradykinin (BK), a B2 receptor agonist (B2R), constitutively expressed. Kininase I acts on BK and produces des-Arg9-bradykinin (DABK), which binds to the B1 receptor (B1R), induced by inflammation. In the liver, BK induces portal hypertensive response mediated…
Biological and pharmacological effects of bradykinin (BK) are mediated by two receptors: the constitutive B2 (B2R) and the inducible B1 (B1R). BK has a role in the hepatic microcirculation by induction of portal hypertensive response (PHR) via B2R, since des-arg9-BK (DABK), a B1R agonist, did not elicit response. During ischemia-reperfusion injury, important changes in the microcirculatio…
Copaíba oil is extracted from the tree trunks of Copaíba and its medicinal properties were known to the Indians to observe that the animals rubbed themselves in the copaíba trees to heal their wounds. Various properties are now known as anti-inflammatory, antitumor, antineoplastic and trypanosomicides. The popular use in Diabetes is well known, but no scientific work has proven this effec…
The low-level laser therapy has been extensively investigated as an anti-inflammatory and wound healing method. Previous studies have shown the effectiveness of low-level laser therapy in visceral organs, however little is known about its effect on the liver. Objectives: To investigate the therapeutic effects of low-level laser therapy in the liver fibrogenesis using an experimental model…
Kinins are peptides formed by 8-11 amino acids, such as bradykinin, kallidin and their metabolites. It has biological action through the binding to membrane receptors B1 and B2. It has indirect vasodilator action, because stimulates the nitric oxide release and is related to inflammatory conditions. In the arterial system, bradykinin has a hypotensive action, whereas in the portal system …
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| 4 / 2 | Completed research grants |
| 18 / 12 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 23 / 14 | All research grants and scholarships |
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CV Lattes
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