Graduated in Physiotherapy from Universidade Metodista de Piracicaba (1998), Ph.D. in Science (Experimental Pathophysiology) from Universidade de São Paulo (2005) and post-doctorate in Pulmonary Pathophysiology at FMUSP (2008). In 2008, she joined as adjunct professor at the Federal University of São Paulo, Dept of Biological Sciences, Campus Diadema, where she worked until 2015. Now she is currently Associate Professor III at the Dept of Biosciences, Institute of Health and Society, Baixada Santista Campus of the Federal University from São Paulo where she coordinates the Laboratory for Studies in Pulmonary Inflammation. She also works as a collaborating researcher at the Experimental Therapeutics Laboratory I of the Faculty of Medicine of the University of São Paulo. She has expertise in the field of pathophysiology and pulmonary histopathology, acting on the following topics: inflammatory mediators, experimental models of lung inflammation, bronchial asthma, pulmonary emphysema, acute lung injury, lung remodeling, anti-inflammatory cholinergic system and effects of phytochemical compounds in lung diseases. She was coordinator of the Graduate Program in Chemical Biology from 2012 to 2015. She is a collaborating advisor of the Medical Sciences Program in the area of inflammatory and allergic processes at the Faculty of Medicine of the University of São Paulo and permanent advisor in the Interdisciplinary Science Program of Unifesp Health, Baixada Santista Campus. (Source: Lattes Curriculum)
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SARS-CoV-2 (Severe Acute Respiratory Syndrome, Coronavirus 2) is the virus that causes COVID-19 (Coronavirus disease 2019), declared as a pandemic in March / 2020, which in its severe form leads to death due to acute lung injury (ALI), refractory hypoxemia and the presence of microthrombi. The virus enters the cell after binding the Spike protein to ACE2 (angiotensin-converting enzyme 2).…
According to DATASUS data, respiratory diseases, including asthma, emphysema, pneumonia, bronchitis and bronchiolitis, have led to more than 135,000 deaths in 2017. The acute respiratory distress syndrome (ARDS) affects 2% to 26% of all mechanical ventilation hospitalized in intensive care centers is characterized by a diffuse pulmonary inflammatory response that causes acute lung injury …
The anti-inflammatory cholinergic system (SCAI), described a few years ago, has been not fully investigated in the lung and may be an important therapeutic target for the treatment of pulmonary diseases. We recently demonstrated that animals with VAChT deficiency, the protein which transports acetylcholine (ACh), developed inflammation, activation of the NF-kB and reduction of JAK2-STAT3-…
Background: Pulmonary emphysema is characterized by irreversible airflow obstruction, inflammation, oxidative stress imbalance and lung remodeling, resulting in reduced lung function and a lower quality of life. Flavonoids are plant compounds with potential anti-inflammatory and antioxidant effects that have been used in folk medicine. Our aim was to determine whether treatment with sakur…
(Only some records are available in English at this moment)
Asthma is a chronic airway disease characterized by chronic inflammation, bronchial hyperresponsiveness and airway remodeling. It is known that there are also inflammatory and remodeling changes in the most distal regions including the pulmonary parenchyma and in the peribronchial vessels. Although the recommended treatment is the use of inhaled corticosteroids associated with long-acting…
The chronic obstructive pulmonary disease (COPD) is a progressive disease, characterized by limited airflow due to abnormalities of the airways and alveoli, usually caused by exposure to harmful particles and gases, mainly due to smoking. COPD encompasses both chronic bronchitis and emphysema, the latter being the subject of the present study. Pulmonary emphysema is an anatomopathological…
Acute lung injury (ALI) is characterized by sudden onset, polymorphonuclear cells recruitment and release of pro-inflammatory mediators, which can induce changes in cytokines. The reduction of vesicular transport of acetylcholine (VAChT) reduces the release of ACh, the main mediator of anti-inflammatory cholinergic system (AICS), modulating pulmonary inflammation. Aims: To evaluate the ef…
(Only some records are available in English at this moment)
Acute lung injury (ALI) is characterized by sudden onset, polymorphonuclear cells recruitment and release of pro-inflammatory mediators, which can induce changes in cytokines. The reduction of vesicular transport of acetylcholine (VAChT), which is associated to reduction on the release of ACh, the main mediator of cholinergic anti-inflammatory system, modulates pulmonary inflammation. Nic…
| 1 / 1 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 18 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 25 / 16 | All research grants and scholarships |
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CV Lattes
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