Silvia Beatriz Boscardin graduated in Biological Sciences - Medical Modality from the Federal University of São Paulo/Paulista School of Medicine in 1996. She completed her master's degree in 1999 and her doctorate in 2003, both in Microbiology and Immunology, at the same institution. From 2003 to 2008, she conducted her postdoctoral research at the Laboratory of Molecular Immunology at Rockefeller University in New York, United States. Currently, she serves as an associate professor with tenure in the Department of Parasitology at the Institute of Biomedical Sciences of the University of São Paulo (USP). Her current projects focus on the use of monoclonal antibodies (mAbs) in vaccination strategies and treatments for various infectious diseases. The application of chimeric mAbs, which can direct specific antigens to conventional dendritic cells (cDCs), has shown promise in developing vaccines against malaria, dengue, and cancer related to the human papillomavirus (HPV). Research from her group indicates that chimeric mAbs, targeted at two distinct subpopulations of cDCs (cDC1 and cDC2), when administered with adjuvants that promote their maturation, are potent immunogens capable of inducing long-lasting cellular and humoral immune responses against the target antigen. Additionally, her group has successfully developed human-specific mAbs for treating infections caused by the dengue virus (DENV), Zika virus (ZIKV), and SARS-CoV2. In the long term, the aim is to deepen studies with chimeric mAbs that direct antigens to cDCs, focusing on HPV and malaria models, to evaluate the immunological mechanisms involved in protection in experimental models. Furthermore, in a more applied context, the goal is to investigate the protective effect during pregnancy of a fully human anti-ZIKV mAb, which has demonstrated the ability to protect animals of a highly susceptible lineage (AG129) from a lethal challenge with ZIKV and DENV-2, as well as to develop fully human mAbs against the infective form of Plasmodium vivax. She is involved with the National Institute of Science and Technology for Investigation in Immunology (INCTiii) and the Vaccine Research Center (NPV) at USP. (Source: Lattes Curriculum)
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Dengue virus (DENV) and Zika virus (ZIKV) infections are extremely important for public health, being endemic in 141 countries. Although most signs and symptoms of the disease are mild and self-limiting, it is known that grave infections by DENV and ZIKV can lead to complications. According to data from the Pan American Health Organization, all four DENV serotypes lead to approximately 50…
Microneedles (MNs) form a safe and non-invasive drug-delivery platform for topic and systemic applications. Biocompatibility, easy application, improved efficiency-controlled release, and low concentrations needed are among the main benefits of the technology. Technologies based on MNs can increase the population's access to cutting-edge therapies through reduced costs and increase the we…
Dengue virus (DENV) and Zika virus (ZIKV) infections are extremely important for public health, being endemic in 141 countries. Although most signs and symptoms of the disease are mild and self-limiting, it is known that grave infections by DENV and ZIKV can lead to complications. According to data from the Pan American Health Organization, all four DENV serotypes lead to approximately 5…
In the mouse spleen, there are mainly two subtypes of dendritic cells (DCs), one expressing the endocytic receptor CD205 (DEC205) and the alpha chain of the CD8 receptor (DEC205+CD8±+), and another expressing the DCIR2 endocytic receptor, but not the the CD8± molecule (DCIR2+CD8±-). The DEC205+CD8±+ subtype has the ability to instruct CD4+ T lymphocytes, and to cross-present extracellular…
The Institute for Investigation in Immunology, iii, initially a Millenium Institute created in 2001, studies infectious diseases, HIV/AIDS, allergy, autoimmune diseases, transplantation and primary immunodeficiency. These diseases have strong immunological components, and are health problems that affect millions in our country and throughout the world. Besides the social and economic rele…
(Only some records are available in English at this moment)
Zika fever is caused by a flavivirus named Zika virus (ZIKV), which belongs to the Flaviriridae family. This virus has been linked to a significant increase in the number of babies born with microcephaly due to maternal infection. Monoclonal antibodies (mAbs) have been widely used for treating viral infections; however there is currently no licensed mAb for ZIKV control. Previous studies …
Zika fever is caused by a flavivirus belonging to the Flaviviridae family called the Zika virus (ZIKV). Infection with this virus has been associated with a significant increase in the number of babies with microcephaly born to infected mothers. In fact, intrauterine ZIKV infection causes a distinct pattern of birth defects and disabilities in the developing fetus and newborn, called Cong…
Splenic conventional Dendritic Cells (cDCs) are central in the process of inducing the immune response, as they are capable of presenting antigens from different pathogens and inducing the activation of naive T cells. In mice, splenic cDCs are often classified into cDC1 (expressing the alpha chain of the CD8 molecule and the endocytic receptor DEC205, CD8±+DEC205+) and into cDC2 (CD8± neg…
The diagnosis of parasites of the Oxyuridae family is critical for the sanitary control of animals used in research, especially those of the genus Syphacia spp., common in rodents. Examinations considered the 'gold standard' by the Federation of European Laboratory Animal Science Associations (FELASA) involve evaluating the intestinal content of the animal. This procedure has limitations,…
The genus Flavivirus is composed of single-stranded positive-sense RNA genome viruses, comprising different viruses, such as dengue virus serotype 2 (DENV-2) and ZIKA virus (ZIKV), both of great importance in public health in Brazil. Flaviviruses are structurally similar, and this similarity is responsible for the induction of cross-reacting antibodies, which mainly target the envelope (E…
Coronavirus Disease 2019 (COVID-19) is caused by SARS-CoV-2 virus and has achieved pandemic character at the beginning of 2020. Virus entry in host cells is mediated by spike (S) proteins, which are densely glycosylated proteins present in SARS-CoV-2 envelope, by binding its structure to Angiotensin-Converting Enzyme 2 receptor (ACE-2). Previous studies have shown that this interaction is…
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Monoclonal antibodies have emerged as important candidates for the treatment and prevention of various diseases, including cancer, autoimmune diseases and, more recently, infectious diseases. Malaria remains the deadliest vector-borne infection globally and is caused by the inoculation of Plasmodium spp sporozoites during the bite of an infected mosquito. Despite being responsible for ove…
| 2 / 2 | Ongoing research grants |
| 8 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 21 / 17 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 35 / 30 | All research grants and scholarships |
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