Dr. Silvia Beatriz Boscardin has a degree in Biological Sciences - Medical Modality from the Federal University of São Paulo (1996). She has a master's degree (1999) and a PhD (2003) in Microbiology and Immunology from the Federal University of São Paulo. She did her postdoctoral studies at the Molecular Immunology Laboratory at Rockefeller University (New York, United States) between 2003 and 2008. She is currently an associate professor at the Department of Parasitology / Institute of Biomedical Sciences of the University of São Paulo (USP). She has experience in Parasitology and Immunology, with emphasis on the development vaccination strategies against parasites and viruses. Current projects involve the use of a strategy aimed at targeting pathogen-derived proteins (more specifically Plasmodium and dengue virus) to dendritic cells (DCs) that are responsible for activating the adaptive immune response. She is a member of the Institute for Investigation in Immunology (INCTiii) and USP's Vaccine Research Center (NPV). (Source: Lattes Curriculum)
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Dengue virus (DENV) and Zika virus (ZIKV) infections are extremely important for public health, being endemic in 141 countries. Although most signs and symptoms of the disease are mild and self-limiting, it is known that grave infections by DENV and ZIKV can lead to complications. According to data from the Pan American Health Organization, all four DENV serotypes lead to approximately 5…
In the mouse spleen, there are mainly two subtypes of dendritic cells (DCs), one expressing the endocytic receptor CD205 (DEC205) and the alpha chain of the CD8 receptor (DEC205+CD8±+), and another expressing the DCIR2 endocytic receptor, but not the the CD8± molecule (DCIR2+CD8±-). The DEC205+CD8±+ subtype has the ability to instruct CD4+ T lymphocytes, and to cross-present extracellular…
About half of the world population is at risk of malaria, the deadliest human parasitic disease, responsible for >200 millions of clinical cases and ~700,000 deaths per year. The absence of an effective malaria vaccine is a major hurdle towards the control and elimination of this devastating disease. However, the development of a malaria vaccine is encouraged by the possibility of protect…
Dendritic cells (DCs) are critical for the interaction between the innate and adaptive immune systems, phagocytosing antigens and presenting them to lymphocytes, being able to induce tolerance or strong adaptive responses against pathogens. This property makes these cells interesting targets for the development of new vaccine strategies. Over the past 4 years, we established for the first…
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The diagnosis of parasites of the Oxyuridae family is critical for the sanitary control of animals used in research, especially those of the genus Syphacia spp., common in rodents. Examinations considered the 'gold standard' by the Federation of European Laboratory Animal Science Associations (FELASA) involve evaluating the intestinal content of the animal. This procedure has limitations,…
The genus Flavivirus is composed of single-stranded positive-sense RNA genome viruses, comprising different viruses, such as dengue virus serotype 2 (DENV-2) and ZIKA virus (ZIKV), both of great importance in public health in Brazil. Flaviviruses are structurally similar, and this similarity is responsible for the induction of cross-reacting antibodies, which mainly target the envelope (E…
Splenic conventional Dendritic Cells (cDCs) are central in the process of inducing the immune response, as they are capable of presenting antigens from different pathogens and inducing the activation of naive T cells. In mice, splenic cDCs are often classified into cDC1 (expressing the alpha chain of the CD8 molecule and the endocytic receptor DEC205, CD8±+DEC205+) and into cDC2 (CD8± neg…
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Coronavirus Disease 2019 (COVID-19) is caused by SARS-CoV-2 virus and has achieved pandemic character at the beginning of 2020. Virus entry in host cells is mediated by spike (S) proteins, which are densely glycosylated proteins present in SARS-CoV-2 envelope, by binding its structure to Angiotensin-Converting Enzyme 2 receptor (ACE-2). Previous studies have shown that this interaction is…
Malaria is a serious global public health problem and has become a research priority in vaccine development. Despite continued efforts, there is still no fully effective vaccine against the disease. Several vaccine strategies have been developed using different parasite preparations that induce only partial protection against the infection. In recent years, antigen targeting to dendritic …
Conventional dendritic cells (cDCs) are antigen-presenting cells capable of instructing the adaptive immune response and influencing the polarization of CD4 + T cells. According to the expression of different surface markers, cDCs can be divided into two basic subtypes: CD8a+DEC205+ and CD8a-DCIR2+. Previous results from our laboratory indicate that CD8a+DEC205+ cDCs are able to instruct …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 18 / 14 | Completed scholarships in Brazil |
| 30 / 25 | All research grants and scholarships |
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