Abstract
This project investigates the regulatory role of phosphorylation in modulating protein-protein interactions and chaperone activity of the Hsp90/SGT and Hsp90/Aha1 complex in Leishmania braziliensis. Hsp90 acts as a molecular chaperone assisting in folding, maturation and stabilization of several client proteins, in addition to integrating and coordinating crucial cell signaling pathways. …